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Latest Cilium Stories

2012-04-25 09:45:04

Primary cilia are hair-like structures which protrude from almost all mammalian cells. They are thought to be sensory and involved in sampling the cell's environment. New research, published in BioMed Central's open access journal Cilia, launched today, shows that cilia on cells in the retina and liver are able to make stable connections with each other - indicating that cilia not only are able to sense their environment but are also involved in cell communication. Primary cilia are...

2012-01-12 14:46:41

Discovery may lead to new ways to replace damaged lung tissues with stem cells Scientists at the Salk Institute for Biological Studies have identified a gene that tells cells to develop multiple cilia, tiny hair-like structures that move fluids through the lungs and brain. The finding may help scientists generate new therapies that use stem cells to replace damaged tissues in the lung and other organs. "Cells with multiple cilia play a number of important roles, including moving fluids...

2011-12-14 10:10:38

A new study, conducted by researchers at the University of California, San Francisco, has shed new light on a genetic disease known as Bardet-Biedl syndrome (BBS)–a condition in which patients show mental and developmental delays, short stature, early onset blindness, extra digits on the hands and feet, kidney abnormalities and obesity. While the occurrence of BBS is rare–occurring in roughly 1 in every 150,000 live births–scientists believe that by understanding the...

2011-12-06 23:15:40

Research presented at ASCB annual meeting Is obesity a ciliopathy, a disorder such as polycystic kidney disease (PKD), which is triggered by a defect in the microscopic hair-like cilia that protrude from virtually every cell of humans and other vertebrates? University of Alabama, Birmingham (UAB) researchers told the American Society for Cell Biology (ASCB) 2011 Annual Meeting in Denver on Dec. 6 that mutations in primary cilia may scramble signaling pathways in the hypothalamus, the...

2011-10-18 13:14:01

Ciliary beating of Platynereis gives insights into an ancestral state of nervous system evolution As planktonic organisms the larvae of the marine annelid Platynereis swim freely in the open water. They move by activity of their cilia, thousands of tiny hair-like structures forming a band along the larval body and beating coordinately. With changing environmental conditions the larvae swim upward and downward to their appropriate water depth. Scientists of the Max Planck Institute for...

2011-10-10 19:36:30

Huntington disease is a devastating neurogenerative disorder that causes a progressive loss of functional capacity and reduced life span. It is an inherited condition caused by a mutant HTT gene. Although this has been known for many years, the functions of the normal Htt protein and the mechanisms by which the mutant protein generated from the mutant HTT gene causes disease are not well understood. A team of researchers led by Frédéric Saudou, at the Institut Curie,...

2011-07-11 17:52:27

Researchers at the University of California, San Francisco and in Michigan, North Carolina and Spain have discovered how genetic mutations cause a number of rare human diseases, which include Meckel syndrome, Joubert syndrome and several other disorders. The work gives doctors new possible targets for designing better diagnostics to detect and drugs to treat these diseases, which together affect perhaps one in 200 people in the United States. On the surface, these diseases look very...

2011-06-20 19:53:33

Scientists at Karolinska Institutet have discovered that a gene linked to dyslexia has a surprising biological function: it controls cilia, the antenna-like projections that cells use to communicate. Dyslexia is largely hereditary and linked to a number of genes, the functions of which are, however, largely unknown. This present study from Karolinska Institutet and Helsinki University now shows that one of these genes, DCDC2, is involved in regulating the signalling of cilia in brain...

2011-06-13 15:44:08

The Aurora A kinase may contribute to polycystic kidney disease (PKD) by inactivating a key calcium channel in kidney cells, according to a study in the June 13 issue of The Journal of Cell Biology (www.jcb.org). Aurora A is an oncogene best known as a regulator of mitotic progression. But the kinase has important functions during interphase as well, when it can promote cilia disassembly and can be activated by elevated calcium levels. Because both calcium signaling and cilia are defective in...

2011-04-05 00:05:23

Discovery points to a potential co-contributor to cilia-related diseases Researchers at the University of Massachusetts Medical School have described a previously unknown role for the cilia protein IFT88 in mitosis, the process by which a dividing cell separates its chromosomes containing the cell's DNA into two identical sets of new daughter cells. Published in advance online by Nature Cell Biology, this newly discovered function for IFT88 suggests a possible alternative or contributory...


Word of the Day
cenobite
  • One of a religious order living in a convent or in community; a monk: opposed to anchoret or hermit (one who lives in solitude).
  • A social bee.
This word comes from the Latin 'coenobium,' convent, which comes from the Greek 'koinobios,' living in community.
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