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Latest Cilium Stories

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2011-01-24 08:10:00

Despite what you might have heard, genetic sequencing alone is not enough to understand human disease. Researchers at Duke University Medical Center have shown that functional tests are absolutely necessary to understand the biological relevance of the results of sequencing studies as they relate to disease, using a suite of diseases known as the ciliopathies which can cause patients to have many different traits. "Right now the paradigm is to sequence a number of patients and see what may be...

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2010-12-07 07:44:26

By Kitta MacPherson, Princeton University A gene that can cause congenital heart defects has been identified by a team of scientists, including a group from Princeton University. The discovery could lead to new treatments for those affected by the conditions brought on by the birth defect. Princeton researchers focused on identifying and studying the gene in zebrafish embryos, and the team's work expanded to include collaborations with other groups studying the genetics of mice and people....

2010-09-25 00:25:34

Man-made, hair-like structures poised to change industry paradigms University of Southern Mississippi scientists recently imitated Mother Nature by developing, for the first time, a new, skinny-molecule-based material that resembles cilia, the tiny, hair-like structures through which organisms derive smell, vision, hearing and fluid flow. While the new material isn't exactly like cilia, it responds to thermal, chemical, and electromagnetic stimulation, allowing researchers to control it and...

2010-09-07 13:07:40

A new study in the September 6 issue of the Journal of Cell Biology (www.jcb.org) helps define the role of an important ciliary protein, CEP290. The results could be applied toward targeted gene therapy in cilia-related diseases. Mutations in human CEP290 cause cilia-related disorders that range in severity from isolated blindness to perinatal death. CEP290 mutations are known to cause Meckel syndrome, Joubert syndrome, and NPHP"”the most common syndromic form of cystic kidney disease...

2010-07-07 15:45:15

Japanese team hopes new discovery will aid in creation of therapies for visual, hearing problems It's safe to say that cilia, the hairlike appendages jutting out from the smooth surfaces of most mammalian cells, have long been misunderstood "“ underestimated, even. Not to be confused with their whiplike cousins flagella, which propel sperm, one type of cilia has been known to serve as microscopic conveyor belts. (Picture cilia reaching up like concertgoers supporting a crowd-surfer.)...

2010-06-25 13:25:23

Nearly all mammalian cells have what's called a primary cilium "” a single, stump-like rod projecting from the smooth contours of the cell's outer membrane. Unlike its more flamboyant cousins, the motile cilia, which beat industriously in packs to clear our airways of mucous or to shuttle a fertilized egg to the uterus, the primary cilium just "¦ sits there. Like a bump on a log. In fact, it looks so useless that, until recently, many scientists considered it to be just a...

2010-05-31 13:13:10

An international group of researchers has identified the genetic cause of an inherited condition that causes severe fetal abnormalities. The work, co-led by geneticists at the UCSD Institute for Genomic Medicine, together with colleagues from institutes and universities in Paris, Rome and England, should allow couples at risk of conceiving babies with the profoundly disabling Meckel-Gruber and Joubert syndromes to be identified beforehand through genetic screening. The researchers' findings...

2010-05-31 13:04:07

An international group of researchers has identified the genetic cause of an inherited condition that causes severe foetal abnormalities. The work, co-led by geneticists at the University of Leeds, together with colleagues from institutes and universities in Paris, Rome and San Diego, should allow couples at risk of conceiving babies with the profoundly disabling Meckel-Gruber and Joubert syndromes to be identified beforehand through genetic screening. Their findings, which show how the...

2010-05-17 08:36:47

Patients who encounter serious lung diseases in middle age, despite an absence of family history or other predisposing factors, may still have their genes to blame, according to a new study conducted by researchers at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. The study also determined that the use of a simple screening test may help identify those genetic abnormalities and allow detection before the onset of disease. "Earlier reports...

2010-04-07 08:45:30

New research in the FASEB Journal shows that bone cells use microscopic hair-like projections, called cilia, to turn on bone-forming genes in response to mechanical loads For osteoporosis patients unable to exercise, help may be on the way. That's because scientists have discovered precisely how mechanical stress, such as exercise, promotes new bone growth. This opens the door to entirely new therapies that can trick bones into thinking they are getting a workout. The research report...


Word of the Day
cacodemon
  • An evil spirit; a devil.
  • A nightmare.
  • In astrology, the twelfth house of a scheme or figure of the heavens: so called from its signifying dreadful things, such as secret enemies, great losses, imprisonment, etc.
'Cacodemon' comes from a Greek term meaning 'evil genius.'
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