Latest Click chemistry Stories
Thiols are sulfur-containing molecules found in most proteins of the human body. Characterized by their 'garlicky' smell, they also give coffee, sweat and the spray of skunks their unique odor. Because they are so widespread in biology, medicine and materials science, thiols are ideal targets for connecting molecules like drugs or polymers together, except that they must first be fitted with a chemical group that acts like an adaptor to other molecules. One of the most potentially useful of...
Scientists with Berkeley Lab and Einstein College of Medicine Extend Conventional Click Chemistry to Living Cells Biomolecular imaging can reveal a great deal of information about the inner workings of cells and one of the most attractive targets for imaging are glycans "“ sugars that are ubiquitous to living organisms and abundant on cell surfaces. Imaging a glycan requires that it be tagged or labeled. One of the best techniques for doing this is a technique called click chemistry....
For the first time, the widely used molecular synthesis technique known as click chemistry has been safely applied to a living organism. Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have crafted a unique copper-free version of click chemistry to create biomolecular probes for in vivo studies of live mice. Conventional click chemistry reactions require a copper catalyst that is toxic to cells and organisms. "We developed a...
- A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
- A gentle breeze; a waft; a breath.
- Any rumor that engages general attention.
- A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
- To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
- To breathe in or as in sleep.
- To utter in a whining or monotonous tone.