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Latest Clusterin Stories

2014-07-15 12:28:31

Two drugs to be studied in North America and Europe in volunteers at high risk for disease COPENHAGEN, Denmark, July 15, 2014 /PRNewswire/ -- Researchers from the Banner Alzheimer's Institute (BAI) today announced a partnership with Novartis in a pioneering medical trial to determine whether two investigational anti-amyloid drugs--an active immunotherapy and an oral medication--can prevent or delay the emergence of symptoms of Alzheimer's in people at particularly high risk for...

Missing Hormone 'Leptin' Found In Birds
2014-03-26 12:32:02

The University of Akron How does the Arctic tern (a sea bird) fly more than 80,000 miles in its roundtrip North Pole-to-South Pole migration? How does the Emperor penguin incubate eggs for months during the Antarctic winter without eating? How does the Rufous hummingbird, which weighs less than a nickel, migrate from British Columbia to Mexico? These physiological gymnastics would usually be influenced by leptin, the hormone that regulates body fat storage, metabolism and appetite....

2014-03-05 12:27:31

LEARN Project will Track Cognitive Change in a Comparison Group of Older Individuals, and Initiate the First Tau Imaging Study in a Longitudinal Prevention Trial CHICAGO, March 5, 2014 /PRNewswire-USNewswire/ -- The Alzheimer's Association today announced its largest ever research grant - $8 million over four years - to support the Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) study as a companion study to the Anti-Amyloid Treatment in Asymptomatic Alzheimer's...

2013-04-18 13:36:29

Ever since the appetite-regulation hormone called leptin was discovered in 1994, scientists have sought to understand the mechanisms that control its action. It was known that leptin was made by fat cells, reduced appetite and interacted with insulin , but the precise molecular details of its function –details that might enable the creation of a new treatment for obesity – remained elusive. Now, University of Texas Medical Branch at Galveston researchers have revealed a...

2012-04-24 10:01:08

Without p-tau protein present, impact of amyloid is 'not significantly different from zero' According to a new study, the neuron-killing pathology of Alzheimer's disease (AD), which begins before clinical symptoms appear, requires the presence of both amyloid-beta (a-beta) plaque deposits and elevated levels of an altered protein called p-tau. Without both, progressive clinical decline associated with AD in cognitively healthy older individuals is "not significantly different from...

2012-01-23 21:51:13

A group of researchers led by the Institute of Biotechnology and Biomedicine (IBB) and Universitat Autònoma de Barcelona (UAB) have achieved to quantify with precision the effect of protein aggregation on cell aging processes using as models the Escherichia coli bacteria and the molecule which triggers Alzheimer's disease. Scientists demonstrated that the effect can be predicted before it occurs. Protein aggregation is related to several diseases, including neurodegenerative...

2011-08-29 12:04:04

Preventing the formation of amyloid fibrils A molecule which can stop the formation of long protein strands, known as amyloid fibrils, that cause joint pain in kidney dialysis patients has been identified by researchers at the University of Leeds. The discovery could lead to new methods to identify drugs to prevent, treat or halt the progression of other conditions in which amyloid fibrils play a part, including Alzheimer's, Parkinson's and Type II diabetes. The research, funded by...

2010-07-06 12:27:05

Higher concentrations of clusterin, a protein in the blood plasma, appears to be associated with the development, severity and progression of Alzheimer's disease, according to a report in the June issue of Archives of General Psychiatry, one of the JAMA/Archives journals. Individuals with Alzheimer's disease display several findings in their blood and cerebrospinal fluid that may reflect neuropathological changes, according to background information in the article. For instance, in...

2010-04-21 09:22:50

New research study published in the Journal of Alzheimer's Disease Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people worldwide and has become a major global concern. Uncontrolled oligomerization (aggregation) of AÃŽ² peptide is the hallmark of AD and it is believed to be causally related to AD pathomechanism. Intensive research (biophysical, animal model and clinical) is underway to investigate the cause of this unexplained aggregation of...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.