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Latest Co-stimulation Stories

2014-02-14 11:15:45

Newborns are more susceptible to infections, presumably because of their immature and inexperienced immune systems. The most common dangerous condition in newborns and infants are lower respiratory tract infections caused by viruses, especially respiratory syncytial virus (RSV). A study published on February 13th in PLOS Pathogens shows how the immune system in the lungs during early life differs from the one in older children and adults. Ideally, newborns could be protected against RSV by...

2010-09-03 12:33:58

New findings may lead to the development of more effective therapies for inflammation, wounds and malignant tumors In two closely related studies, two teams of Scripps Research Institute scientists have discovered the underlying mechanisms that activate a type of immune cell in the skin and other organs. The findings may lead to the development of new therapies to treat inflammation, wounds, asthma, and malignant tumors. The results of the two companion studies were published in the September...

2010-08-04 09:08:00

ROCKVILLE, Md., Aug. 4 /PRNewswire/ -- Amplimmune, Inc. today announced that it has entered into a broad strategic alliance with GlaxoSmithKline (GSK) to further develop PD-1 targeting therapies that may be effective in the treatment of cancer and other diseases. GSK will obtain exclusive worldwide rights to AMP-224 as well as other potential next generation fusion proteins that target PD-1. Under the terms of this agreement, GSK will pay Amplimmune a non-refundable upfront payment of...

2008-08-26 03:00:17

By Rajavelu, Priya Das, Sulochana D Background & objectives: Activation of T cells is mediated through two critical signals provided by activated macrophages. The first signal is triggered when T cell receptor (TCR) binds to the major histocompatibility antigen (MHC/Ag) complex. The second signal is the interaction of co-stimulatory molecules with their respective ligands on T cells for their activation and proliferation. We undertook this study to observe the modulation in B7.1 (CD80)...

2005-08-25 11:35:19

In an international clinical trial, a new drug that selectively blocks immune responses has proved as effective in preventing acute kidney transplant rejection as cyclosporine, the standard anti-rejection treatment. Patients who took the experimental drug, a co-stimulatory blocker called belatacept (LEA29Y), also had better kidney function and experienced less of the toxic side effects associated with standard anti-rejection drugs, including kidney damage, high blood pressure and high...

2005-07-28 14:20:00

A group of scientists at The Scripps Research Institute has solved a mystery that has dogged immunologists for many years: how T-cell receptors interact with their coreceptor proteins at the beginning of an immune response. T-cell receptors and coreceptor molecules are both large proteins displayed on the surface of T cells, and they play an essential role during the beginning of an immune response. T cells become activated after their T-cell receptor recognizes antigen -- small pieces of...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.