Latest Cocaine and amphetamine regulated transcript Stories

2012-04-23 11:18:35

New research from Mount Sinai Medical Center in New York reveals that repeated exposure to cocaine decreases the activity of a protein necessary for normal functioning of the brain's reward system, thus enhancing the reward for cocaine use, which leads to addiction. Investigators were also able to block the ability of repeated cocaine exposure, to induce addiction. The findings, published online April 22 in the journal Nature Neuroscience, provide the first evidence of how cocaine changes the...

2012-01-11 15:30:17

Research published by Cell Press in the January 12 issue of the journal Neuron provides fascinating insight into a newly discovered brain mechanism that limits the rewarding impact of cocaine. The study describes protective delayed mechanism that turns off the genes that support the development of addiction-related behaviors. The findings may lead to a better understanding of vulnerability to addiction and as well as new strategies for treatment. Drug addiction is associated with...

2011-07-12 12:36:36

New animal research demonstrates gut hormone-induced changes in dopamine release New research findings to be presented at the upcoming annual meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, finds that ghrelin, a natural gut hormone that stimulates feeding, also modulates the ability of tasty food and food-related cues to alter dopamine levels within the striatum, a critical component of the...

2009-05-18 23:52:55

U.S. researchers have found cocaine regulated molecular pathways that may lead to addiction treatments. The study, published in Cell Press, finds long-lasting changes in behavior are elicited as cocaine regulates gene expression in a crucial reward region of the brain. Although we have known for some time that changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry that is seen during drug addiction, how those specific genes are regulated is not...

2009-04-17 01:02:09

Initial drug use can be motivated by curiosity or peer pressure, but in some animals it can result from a stressful event, researchers in Puerto Rico said. Natasha Lugo-Escobar, Nicole Carreras and Annabell C. Segarra of University of Puerto Rico School of Medicine in Rio Piedras, Puerto Rico, said drugs act on the reward centers of the brain. These areas are normally involved in mediating pleasure, and also regulate the psychostimulant effects of drugs such as cocaine. Stress is known to...

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