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Last updated on April 17, 2014 at 8:56 EDT

Latest Cold Spring Harbor Laboratory Stories

2014-03-28 09:19:23

In recent years, behavioral neuroscientists have debated the meaning and significance of a plethora of independently conducted experiments seeking to establish the impact of chronic, early-life stress upon behavior – both at the time that stress is experienced, and upon the same individuals later in life, during adulthood. These experiments, typically conducted in rodents, have on the one hand clearly indicated a link between certain kinds of early stress and dysfunction in the...

2014-01-20 10:34:39

Normally, tissue injury triggers a mechanism in cells that tries to repair damaged tissue and restore the skin to a normal, or homeostatic state. Errors in this process can give rise to various problems, such as chronic inflammation, which is a known cause of certain cancers. "It has been noted that cancer resembles a state of chronic wound healing, in which the wound-healing program is erroneously activated and perpetuated," says Professor Adrian Krainer of Cold Spring Harbor Laboratory...

Tweaking A 'Hybrid Vigor' Gene Could Generate Higher Crop Yields
2013-12-27 06:46:05

Cold Spring Harbor Laboratory Every gardener knows the look of a ripe tomato. That bright red color, that warm earthy smell, and the sweet juicy flavor are hard to resist. But commercial tomato plants have a very different look from the backyard garden variety, which can grow endlessly under the right conditions to become tall and lanky. Tomatoes that will be canned for sauces and juice are harvested from plants that stop growing earlier than classic tomato varieties, and are therefore...

2013-11-27 15:37:32

Discovery also reveals how a drug, now in multiple human trials, halts production of Myc protein and stops progression of AML A team of researchers at Cold Spring Harbor Laboratory (CSHL) has identified a leukemia-specific stretch of DNA called an enhancer element that enables cancerous blood cells to proliferate in Acute Myeloid Leukemia (AML), a devastating cancer that is incurable in 70% of patients. Just as important, the findings offer a mechanistic insight into how a new class of...

Skin Microbiome Shaped By Human Immune System
2013-10-29 13:50:14

Cold Spring Harbor Laboratory Our skin plays host to millions of beneficial and potentially disease-causing microorganisms; however, whether our immune system influences these microbial communities to prevent disease is unknown. In a study published online in Genome Research, researchers have explored the microbes living on the skin of patients with primary immunodeficiencies with eczema-like skin conditions. The human body contains many microbes, some of which are necessary for healthy...

2013-10-21 13:38:31

Think of the smell of an orange, a lemon, and a grapefruit. Each has strong acidic notes mixed with sweetness. And yet each fresh, bright scent is distinguishable from its relatives. These fruits smell similar because they share many chemical compounds. How, then does the brain tell them apart? How does the brain remember a complex and often overlapping chemical signature as a particular scent? Researchers at Cold Spring Harbor Laboratory (CSHL) are using the fruit fly to discover how the...

2013-10-07 12:19:08

Inhibitory neuron type found to specifically suppress activation of other inhibitory neurons in cerebral cortex The cerebral cortex contains two major types of neurons: principal neurons that are excitatory and interneurons that are inhibitory, all interconnected within the same network. New research now reveals that one class of inhibitory neurons – called VIP interneurons -- specializes in inhibiting other inhibitory neurons in multiple regions of cortex, and does so under specific...

2013-10-03 16:09:36

Psychiatrist, geneticist, neurosurgeon and genome sequencers generate data on one patient,with big implications for care A multidisciplinary team led by a geneticist and psychiatrist from Cold Spring Harbor Laboratory's (CSHL) Stanley Institute for Cognitive Genomics today publish a paper providing a glimpse of both the tremendous power and the current limitations of what is sometimes called "precision medicine." Precision medicine is an approach to diagnosis and treatment that tailors...

2013-09-20 11:09:42

Study highlights therapeutic importance of targeting a broad set of signals between cancer cells and normal cells that support them Investigators at Cold Spring Harbor Laboratory (CSHL) today report important progress in research aimed at finding ways to fight cancer by targeting the local environment in which tumors grow and from which they draw sustenance. The targeting of interactions between cancer cells and their environment together with the traditional tactic of directly...

2013-09-10 23:19:50

As VP of Business Development & Technology Transfer, Willey will build on strong record of success in venture capital and research commercialization Cold Spring Harbor, NY (PRWEB) September 10, 2013 Cold Spring Harbor Laboratory (CSHL) today announced that Teri F. Willey has been appointed Vice President of Business Development and Technology Transfer. In this newly created position, Ms. Willey will direct the Laboratory’s commercialization and technology transfer activities,...