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Latest Cold Spring Harbor Laboratory Stories

New Way In Which Plants Control Flower Production Discovered
2012-11-12 11:22:57

Cold Spring Harbor Laboratory Flowers don't just catch our eyes, they catch those of pollinators like bees as well. They have to, in order to reproduce. Because plants need to maximize the opportunity for pollinators to gain access to their seeds, variations in the timing of flowering can have profound effects on flower, fruit, and seed production, and consequently agricultural yields. We know that the major driving forces of flowering are external factors such as light and temperature....

2012-08-15 11:57:20

Targeted 'negative ASOs' cause missplicing and pathogenesis, providing unique window on disease progression A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases — those with pathology caused by errors in the splicing of RNA messages copied from genes. To date, about 6,000 such RNA "editing" errors have been found in various human illnesses, ranging from neurodegenerative disorders...

2012-07-02 12:53:40

Hybrid error-correction approach boosts accuracy of 'long reads' to 99.9 percent The next "next-gen" technology in genome sequencing has gotten a major boost. A quantitative biologist at Cold Spring Harbor Laboratory (CSHL) and collaborators today published results of experiments that demonstrate the power of so-called single-molecule sequencing, which was recently introduced but whose use has so far been limited by technical issues. The team, led by CSHL Assistant Professor Michael...

2012-05-18 23:58:51

Discovery alters prevailing view of splicing regulation and has implications for splicing mutations associated with disease There are always exceptions to a rule, even one that has prevailed for more than three decades, as demonstrated by a Cold Spring Harbor Laboratory (CSHL) study on RNA splicing, a cellular editing process. The rule-flaunting exception uncovered by the study concerns the way in which a newly produced RNA molecule is cut and pasted at precise locations called splice...

2012-05-07 20:30:41

Such deletions could confer survival advantage on tumors, a challenge to '2-hit theory' of tumor suppressor action Scientists at Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan-Kettering Cancer Center have amassed strong experimental evidence implying that commonly occurring large chromosomal deletions that are seen in many cancer types contain areas harboring multiple functionally linked genes whose loss, they posit, confers a survival advantage on growing tumors. Looking...

2012-04-25 20:19:20

A team led by scientists at Cold Spring Harbor Laboratory (CSHL) publishes research today indicating a striking association between genes found disrupted in children with autism and genes that are targets of FMRP, the protein generated by the gene FMR1, whose dysfunction causes Fragile-X syndrome. The new study appears online April 25 in the journal Neuron. Fragile-X syndrome is the most common cause of inherited intellectual disability. It is also counted among the autism spectrum...

2012-04-02 20:37:33

The target, PRC2, is a lysine methyltransferase-containing protein complex with components that can be readily targeted with small molecule inhibitors Scientists at Cold Spring Harbor Laboratory have identified a candidate drug target for treating acute myeloid leukemia (AML), a white blood cell cancer that proliferates out of control in the bone marrow. The team, led by Assistant Professor Chris Vakoc, M.D., Ph.D., shows that blocking a protein called PRC2 halts this uncontrolled...

2012-03-13 21:45:13

Findings establish a model to study how the brain processes multisensory information, a process that goes awry in autism spectrum disorders The next time you set a trap for that rat running around in your basement, here's something to consider: you are going up against an opponent whose ability to assess the situation and make decisions is statistically just as good as yours. A Cold Spring Harbor Laboratory (CSHL) study that compared the ability of humans and rodents to make perceptual...

2012-02-01 10:33:46

Hyperconnectivity triggered by loss of PTEN gene can be blocked by treatment with rapamycin New research from Cold Spring Harbor Laboratory (CSHL) might help explain how a gene mutation found in some autistic individuals leads to difficulties in processing auditory cues and paying spatial attention to sound. The study has found that when a suspected autism gene called PTEN is deleted from auditory cortical neurons–the main workhorses of the brain's sound-processing...

2012-01-16 10:51:22

Facilitates systematic comparison of mouse models of disorders including schizophrenia, autism A new technology developed by neuroscientists at Cold Spring Harbor Laboratory (CSHL) transforms the way highly detailed anatomical images can be made of whole brains. Until now, means of obtaining such images — used in cutting-edge projects to map the mammalian brain -- have been painstakingly slow and available only to a handful of highly specialized research teams. By automating and...