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Latest Cold Spring Harbor Laboratory Stories

2012-07-02 12:53:40

Hybrid error-correction approach boosts accuracy of 'long reads' to 99.9 percent The next "next-gen" technology in genome sequencing has gotten a major boost. A quantitative biologist at Cold Spring Harbor Laboratory (CSHL) and collaborators today published results of experiments that demonstrate the power of so-called single-molecule sequencing, which was recently introduced but whose use has so far been limited by technical issues. The team, led by CSHL Assistant Professor Michael...

2012-05-18 23:58:51

Discovery alters prevailing view of splicing regulation and has implications for splicing mutations associated with disease There are always exceptions to a rule, even one that has prevailed for more than three decades, as demonstrated by a Cold Spring Harbor Laboratory (CSHL) study on RNA splicing, a cellular editing process. The rule-flaunting exception uncovered by the study concerns the way in which a newly produced RNA molecule is cut and pasted at precise locations called splice...

2012-05-07 20:30:41

Such deletions could confer survival advantage on tumors, a challenge to '2-hit theory' of tumor suppressor action Scientists at Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan-Kettering Cancer Center have amassed strong experimental evidence implying that commonly occurring large chromosomal deletions that are seen in many cancer types contain areas harboring multiple functionally linked genes whose loss, they posit, confers a survival advantage on growing tumors. Looking...

2012-04-25 20:19:20

A team led by scientists at Cold Spring Harbor Laboratory (CSHL) publishes research today indicating a striking association between genes found disrupted in children with autism and genes that are targets of FMRP, the protein generated by the gene FMR1, whose dysfunction causes Fragile-X syndrome. The new study appears online April 25 in the journal Neuron. Fragile-X syndrome is the most common cause of inherited intellectual disability. It is also counted among the autism spectrum...

2012-04-02 20:37:33

The target, PRC2, is a lysine methyltransferase-containing protein complex with components that can be readily targeted with small molecule inhibitors Scientists at Cold Spring Harbor Laboratory have identified a candidate drug target for treating acute myeloid leukemia (AML), a white blood cell cancer that proliferates out of control in the bone marrow. The team, led by Assistant Professor Chris Vakoc, M.D., Ph.D., shows that blocking a protein called PRC2 halts this uncontrolled...

2012-03-13 21:45:13

Findings establish a model to study how the brain processes multisensory information, a process that goes awry in autism spectrum disorders The next time you set a trap for that rat running around in your basement, here's something to consider: you are going up against an opponent whose ability to assess the situation and make decisions is statistically just as good as yours. A Cold Spring Harbor Laboratory (CSHL) study that compared the ability of humans and rodents to make perceptual...

2012-02-01 10:33:46

Hyperconnectivity triggered by loss of PTEN gene can be blocked by treatment with rapamycin New research from Cold Spring Harbor Laboratory (CSHL) might help explain how a gene mutation found in some autistic individuals leads to difficulties in processing auditory cues and paying spatial attention to sound. The study has found that when a suspected autism gene called PTEN is deleted from auditory cortical neurons–the main workhorses of the brain's sound-processing...

2012-01-16 10:51:22

Facilitates systematic comparison of mouse models of disorders including schizophrenia, autism A new technology developed by neuroscientists at Cold Spring Harbor Laboratory (CSHL) transforms the way highly detailed anatomical images can be made of whole brains. Until now, means of obtaining such images — used in cutting-edge projects to map the mammalian brain -- have been painstakingly slow and available only to a handful of highly specialized research teams. By automating and...

2011-12-27 08:36:54

Manipulating the clock might provide agricultural benefits, as a slower clock increases branching, thereby increasing flower number and fruit yield The secret to pushing tomato plants to produce more fruit might not lie in an extra dose of Miracle-Gro. Instead, new research from Cold Spring Harbor Laboratory (CSHL) suggests that an increase in fruit yield might be achieved by manipulating a molecular timer or so-called "maturation clock" that determines the number of branches that make...

Genome Tree Of Life Is Largest Yet For Seed Plants
2011-12-17 04:26:21

New York Plant Genomics Consortium maps evolutionary relationships, gene functions for 150 species Scientists at the American Museum of Natural History, Cold Spring Harbor Laboratory, The New York Botanical Garden, and New York University have created the largest genome-based tree of life for seed plants to date. Their findings, published today in the journal PLoS Genetics, plot the evolutionary relationships of 150 different species of plants based on advanced genome-wide analysis of gene...


Word of the Day
monteith
  • A large punch-bowl of the eighteenth century, usually of silver and with a movable rim, and decorated with flutings and a scalloped edge. It was also used for cooling and carrying wine-glasses.
  • A kind of cotton handkerchief having white spots on a colored ground, the spots being produced by a chemical which discharges the color.
This word is possibly named after Monteith (Monteigh), 'an eccentric 17th-century Scotsman who wore a cloak scalloped at the hem.'
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