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Latest Cold Spring Harbor Laboratory Stories

2011-09-27 11:20:26

Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of Southern California (USC) have uncovered intriguing new evidence helping to explain one of the ways in which a stem cell's fate can be determined. The new data show how the "marking" of DNA sequences by groups of methyl molecules — a process called methylation — can influence the type of cell a stem cell will become. The cellular maturation process, called differentiation, has long been thought to be...

2011-09-21 19:44:41

20 mouse lines provide views of cortical GABA neurons not previously possible A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has succeeded in creating what amounts to a GPS system for locating and tracking a vital class of brain cells that until now has eluded comprehensive identification, particularly in living animals. The cells in question are the class of neurons that release the neurotransmitter called GABA (gamma aminobutyric acid). GABA neurons function to...

2011-08-25 21:34:14

Study finds KN1 trafficking through tiny channels called plasmodesmata cannot occur without chaperonins Like all living things, plants depend for their growth and sustenance on elaborate signaling networks to maintain stem cells, cells that have an almost magical regenerative capacity. The signals sent through these networks convey an incredible diversity of instructions, which make it possible for plants to follow genetic and cellular programs regulating growth, shape, and energy...

2011-08-03 13:05:01

grassy tillers1 suppresses branching, enabling maize to grow taller when shade encroaches -- a key to teosinte's ancient domestication When an animal gets too hot or too cold, or feels pangs of hunger or thirst, it tends to relocate "“ to where it's cooler or hotter, or to the nearest place where food or water can be found.  But what about vegetative life?  What can a plant do under similar circumstances? Plants can't change the climate and they can't uproot themselves to move...

2011-08-01 12:51:00

Fusion oncoprotein MLL-AF9 'hijacks' Myb to enforce a program of aberrant self-renewal A team of scientists at Cold Spring Harbor Laboratory (CSHL) has laid bare the mechanism behind a phenomenon called oncogene addiction in mice suffering from a form of leukemia that mimics acute myelogenous leukemia (AML) in humans. Significantly, the team was able to mobilize their newly gained understanding to target "addiction" pathways in the model mice, resulting in rapid and complete eradication of...

2011-06-30 19:19:16

PTPN23 can regulate the SRC oncoprotein; basis for a new therapeutic approach Researchers at Cold Spring Harbor Laboratory (CSHL) have identified an enzyme that appears to be a significant regulator of breast cancer development. Called PTPN23, the enzyme is a member of a family called protein tyrosine phosphatases, or PTPs, that plays a fundamental role in switching cell signaling on and off. When the scientists suppressed the expression of PTPN23 in human mammary cells, they noted a cascade...

2011-06-16 13:21:10

Precisely mapped allosteric binding site will facilitate design of drugs with minimal side effects Structural biologists at Cold Spring Harbor Laboratory (CSHL) have obtained a precise molecular map of the binding site for an allosteric inhibitor in a subtype of the NMDA (N-methyl-D-aspartate) receptor, which is commonly expressed in brain cells. The newly discovered binding site -- a docking port within the receptor -- is important because it is a potential target for drugs that can modulate...

2011-05-09 07:36:49

(Ivanhoe Newswire) -- A new study from Cold Spring Harbor Laboratory (CSHL) offers an explanation for why our brains produce fewer and fewer neurons with age, a phenomenon thought to underlie age-related cognitive decline. The study suggests that this drop in production is due to the shrinking cache of adult stem cells in our brains. "It's only recently that scientists have found hard evidence for the importance of new neuron production in the adult brain's hippocampus, a region critical for...

2011-05-05 22:14:01

Age-related drop in new neurons may be due to 'single use' or 'disposable' nature of adult stem cells in the brain A new study from Cold Spring Harbor Laboratory (CSHL) offers an explanation for why our brains produce fewer and fewer neurons with age, a phenomenon thought to underlie age-related cognitive decline. The study, published as the cover story in the May 6 issue of Cell Stem Cell, suggests that this drop in production is due to the shrinking cache of adult stem cells in our brains....

2011-04-26 23:32:16

Structure of GluN2D subunit when docked with certain neurotransmitters helps explain the receptor's slow deactivation Structural biologists at Cold Spring Harbor Laboratory (CSHL) in collaboration with colleagues at Emory University have determined the molecular structure of a key portion, or subunit, of a receptor type commonly expressed in brain cells. The receptor is one of several NMDA (N-methyl-D-aspartate) receptor variants, and the subunit in question is that which specifically binds...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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