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Latest Cold Spring Harbor Laboratory Stories

2010-12-20 13:38:54

The nucleus of a cell, which houses the cell's DNA, is also home to many structures that are not bound by a membrane but nevertheless exist as distinct compartments. A team of Cold Spring Harbor Laboratory (CSHL) scientists has discovered that the formation of one of these nuclear subcompartments, called paraspeckles, is triggered by a pair of RNA molecules, which also maintain its structural integrity. As reported in a study published online ahead of print on December 19 in Nature Cell...

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2010-12-15 07:48:54

Study might provide new clues to designing better treatments for depression and other neuropsychiatric disorders Shooting steady pulses of electricity through slender electrodes into a brain area that controls complex behaviors has proven to be effective against several therapeutically stubborn neurological and neuropsychiatric disorders. Now, a new study has found that this technique, called deep brain stimulation (DBS), targets the same class of neuronal cells that are known to respond to...

2010-11-01 22:35:57

Imaging has rapidly become a defining tool of the current era in biological research. But finding the right method and optimizing it for data collection can be a daunting process, even for an established imaging laboratory. Cold Spring Harbor Protocols is one of the world's leading sources for detailed technical instruction for implementation of imaging methods(http://cshprotocols.cshlp.org/cgi/collection/imaging_microscopy_general), and the November issue...

2010-10-18 21:45:25

'Sister' mitral cells may broadcast 2 distinct channels of information on odors to the cortex A team co-led by neuroscientists at Cold Spring Harbor Laboratory (CSHL) has shed light -- literally -- on circuitry underlying the olfactory system in mammals, giving us a new view of how that system may pull off some of its most amazing feats. It has long been known from behavioral experiments that rodents, for instance, can tell the difference between two quite similar odors in a single sniff. But...

2010-10-04 16:58:18

Post-translational modifications of histones play an important role in regulating chromatin dynamics and function. One such modification, methylation, is involved in the regulation of the epigenetic program of a cell, determining chromatin structure, and regulating transcription. Methylation of histones occurs on both lysine and arginine residues, and until recently, was thought to be an irreversible process. The recent discovery of histone demethylases revealed that histone methylation is...

2010-09-30 14:42:11

2 Watson School professors find unread correspondence of Francis Crick The story of the double helix's discovery has a few new twists. A new primary source -- a never-before-read stack of letters to and from Francis Crick, and other historical materials dating from the years 1950-76 -- has been uncovered by two professors at the Watson School of Biological Sciences at Cold Spring Harbor Laboratory (CSHL). The letters both confirm and extend current knowledge of the circumstances surrounding...

2010-09-01 20:38:33

Both methods are helpful for investigating the genetic basis of cancer A cell devotes a significant amount of effort to maintaining the stability of its genome, preventing the sorts of chromosomal rearrangements characteristic of many cancers. Assays that measure the rate of gross chromosomal rearrangements (GCRs) are needed in order to understand the individual genes and the different pathways that suppress genomic instability. In the September issue of Cold Spring Harbor Protocols, Richard...

2010-08-30 13:03:34

A federal judge's decision 'sets back' vital work and handcuffs American science Against a backdrop of some of the world's most sophisticated biological research labs, Rep. Steve Israel (D-Huntington) this morning issued a challenge to his colleagues in Congress: immediately upon their return from summer recess, he urged, they should pass legislation that would reverse a recent Federal court decision that has brought embryonic stem cell research in the U.S. to a screeching halt. Rep. Israel...

2010-08-18 03:10:10

CSHL-led team demonstrates that increased IL-6 secretion can lead to decreased sensitivity to Tarceva One of the most tantalizing developments in anti-cancer therapy over recent years has been the advent of targeted treatments, which have proven highly effective in holding aggressive cancers at bay in certain patients, although typically only for a limited period of time. A team led by Raffaella Sordella, Ph.D., an Assistant Professor at Cold Spring Harbor Laboratory (CSHL), today published...

2010-08-12 14:40:05

Understanding how blood stem cells are maintained within the niche offers new opportunities to exploit them therapeutically Hematopoietic stem cells (HSCs) have two unique abilities that are prized by medical researchers: to self-renew and to develop into any kind of blood cell, which enables them to replenish the entire blood and immune system. Scientists have traced these qualities to a distinct locale or niche within the bone marrow that HSCs home in on, but the identity and function of...


Word of the Day
out-herod
  • In the phrase to out-herod Herod, to be more violent than Herod (as represented in the old mystery plays); hence, to exceed in any excess of evil.
Herod refers to 'Herod the Great,' a Roman client king and 'a madman who murdered his own family and a great many rabbis.' According to the OED, the term is 'chiefly with allusion to Shakespeare's use' in Hamlet.
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