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Latest Cold Spring Harbor Laboratory Stories

2010-08-03 14:50:28

Zinc finger nucleases (ZFNs) are artificial restriction enzymes made by fusing an engineered zinc finger DNA-binding domain to the DNA cleavage domain of a restriction enzyme. ZFNs can be used to generate targeted genomic deletions of large segments of DNA in a wide variety of cell types and organisms. In the August issue of the journal Cold Spring Harbor Protocols (http://cshprotocols.cshlp.org/TOCs/toc8_10.dtl), Jin-Soo Kim and colleagues...

2010-07-12 13:26:46

Antisense oligonucleotides delivered into spinal cords of adult and neonatal mice provide a long term rescue from disease symptoms The devastating, currently incurable motor-neuron disease spinal muscular atrophy (SMA) might soon be treated with tiny, chemically modified pieces of RNA called antisense oligonucleotides (ASOs). Scientists at Cold Spring Harbor Laboratory (CSHL) and California-based Isis Pharmaceuticals have succeeded in reversing symptoms of Type III SMA, a relatively mild form...

2010-07-02 20:17:29

Since the early days of the 20th century and Thomas Hunt Morgan's famous "Fly Room" at Columbia University, the fruit fly Drosophila melanogaster has been at the forefront of biological research. The powerful arsenal of experimental methods developed for this model organism is now being used to tackle one of the great scientific challenges of a new century: understanding the nervous system. Cold Spring Harbor Laboratory's Neurobiology of Drosophila course...

2010-07-02 19:46:29

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal of myeloid precursors New research by scientists at Cold Spring Harbor Laboratory (CSHL) has illuminated in fine detail one of the genetic paths that leads to a particularly aggressive form of leukemia. CSHL Professor Scott W. Lowe. Ph.D., an Investigator of the Howard Hughes Medical Institute, led a team of scientists who wanted to know more about how the absence of an important tumor-suppressing protein called p53...

2010-05-06 15:45:20

Researchers from Cold Spring Harbor Laboratory in the USA have developed a powerful new technique for analyzing the genome of single tumor cells. The breakthrough allows them to study in fine detail the biology of how tumors develop and has the potential to help doctors identify dangerous tumor cells from small samples such as fine-needle biopsies from the prostate or a non-invasive lesion in the breast. Dr James Hicks from Cold Spring Harbor described the new technique at the IMPAKT Breast...

2010-04-04 20:00:00

SUZHOU, China, April 4 /PRNewswire-Asia/ -- Cold Spring Harbor Asia (CSHA) is the Asia hub of Cold Spring Harbor Laboratory (CSHL), which is headed by the DNA structure discover, Dr. James D. Watson and President and CEO of CSHL, Dr. Bruce Stillman, who spearhead the effort in molecular medicine and genetics for better diagnostics and treatments for neurological diseases, cancer and other major causes of human suffering. Home to seven Nobel laureates, CSHL has played a pivotal role in the...

2010-03-29 15:24:03

Blocking activity of PI3 kinase signaling protein improves memory By blocking the cellular signaling activity of a protein, a team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has prevented memory loss in fruit flies caused by brain plaques similar to those thought to cause Alzheimer's disease in humans. The study also resolves a long-standing controversy about the role of this protein, PI3 kinase, which was previously thought to have a protective function against the disease....

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2010-03-29 06:10:00

Scientists said in a study released on Sunday that a mutation in a single gene could turn hybrid tomato plants into super producers capable of generating more and much sweeter fruit without genetic engineering. Researcher Zachary Lippman of Cold Spring Harbor Laboratory in New York said the study also showed that using classic plant-breeding techniques can boost yield as dramatically as using genetically modified organisms. Lippman, along with colleagues, reported in the journal Nature...

2010-03-08 09:25:57

Argonaute 9 inhibits asexual reproduction, apparently by silencing transposons One seemingly insurmountable obstacle to the dream of virtually limitless yields of staple crops like corn, wheat and rice is the dependence of those plants on sexual reproduction. When male and female gametes -- sperm and egg -- combine randomly to generate a genetically unique seed, valuable parental traits painstakingly selected by breeders are erased. But what if plants like these could be engineered to...

2010-03-02 09:00:00

BETHPAGE, N.Y., March 2 /PRNewswire/ -- The Lustgarten Foundation announced today that it has formed a national pancreatic cancer research consortium, a collaborative effort involving six world-renowned medical institutions to advance the most promising research initiatives aimed at finding a cure for pancreatic cancer. Named the Pancreatic Cancer Research Consortium (PCRC), The Lustgarten Foundation will provide an initial $10 million in grants this year for research in the prevention,...


Word of the Day
abrosia
  • Wasting away as a result of abstinence from food.
The word 'abrosia' comes from a Greek roots meaning 'not' and 'eating'.