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Latest Copy number variation Stories

2009-06-22 11:39:00

--Whole-Genome Searches Are Revealing Secrets of a Childhood Cancer-- PHILADELPHIA, June 22 /PRNewswire-USNewswire/ -- Two new studies from The Children's Hospital of Philadelphia advance the search for genetic events that result in neuroblastoma, a puzzling, often-deadly type of childhood cancer. Originating in the peripheral nervous system, neuroblastoma is the most common solid cancer of early childhood and causes 15 percent of all childhood cancer deaths. "Only two years ago we had...

2009-06-22 10:03:46

Rearrangements of all sizes in genomes, genes and exons can result from a glitch in DNA copying that occurs when the process stalls at a critical point and then shifts to a different genetic template, duplicating and even triplicating genes or just shuffling or deleting part of the code within them, said researchers from Baylor College of Medicine in a recent report in the journal Nature Genetics. The report further elucidated the effect of the fork stalling and template switching mechanism...

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2009-06-18 06:15:00

In the first ever development of its kind, cancer researchers announced on Wednesday that they have discovered a connection between cancer and a type of genetic mutation that results in either missing or redundant pieces of DNA. The genetic defect, known as a copy number variation, was discovered in neuroblastoma cells, a form of pediatric cancer responsible for some 15 percent of all cancer-related deaths in children. A group of researchers at the Children's Hospital of Philadelphia found...

2009-06-03 13:29:00

ALISO VIEJO, Calif., June 3 /PRNewswire/ -- Ambry Genetics is pleased to announce the launch of whole-genome Chromosomal Microarray Analysis (CMA), offering the Ambry CMA: 105K Oligo Array, which is designed to identify chromosomal abnormalities associated with over 270 genetic disorders. In a partnership with Baylor College of Medicine, Ambry is now able to provide one of the most comprehensive, clinically-validated genetic tests available using array comparative genomic hybridization....

2009-04-16 09:55:21

Database provides a key to unlock the causes of illnesses Today - five years after the inception of the DECIPHER database - researchers have published a report that reveals the developing role of the database in revolutionizing both clinical practice and genetic research. The report explores the growing benefits of DECIPHER for researchers, clinicians and patients - highlighting how the data, provided by around 100 centers and shared openly worldwide, can benefit all three groups. DECIPHER -...

2009-02-10 09:13:46

A new study conducted at the Duke Institute for Genome and Sciences Policy suggests schizophrenia is in part caused by large, rare structural changes in DNA commonly called copy number variants, or CNVs. These new findings dismiss two decades of research that pointed to single letter alterations in DNA (SNPs) as possible candidates. Researchers at Duke scanned the genome of schizophrenia patients and healthy controls for SNPs and CNVs. None of the SNPs appeared significant, but several CNVs...

2008-12-16 10:15:16

A newly published genome sequence of a breast cancer cell line  reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report that appears online in the journal Genome Research. "It's like a computer program that has become buggy and transcends into something dangerous," said Dr. Aleksandar Milosavljevic, associate professor in the BCM Human Genome Sequencing Center. "It...

2008-12-16 09:51:03

A newly published genome sequence of a breast cancer cell line reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report that appears online in the journal Genome Research."It's like a computer program that has become buggy and transcends into something dangerous," said Dr. Aleksandar Milosavljevic, associate professor in the BCM Human Genome Sequencing Center. "It makes...

2008-11-12 06:00:20

Illumina, Inc. (NASDAQ:ILMN) today unveiled a new product for DNA Analysis: the Infinium(R) HD Human660W-Quad BeadChip. This four-sample BeadChip features 2.6 million genetics markers and was developed in collaboration with The Centre for Applied Genomics at the Hospital for Sick Children in Toronto, Canada and the Wellcome Trust Sanger Institute in the United Kingdom. The Human660W-Quad BeadChip builds on the content from Illumina's HumanHap550+ BeadChip to target over 5,000 regions in the...

2008-09-25 09:00:54

Affymetrix Inc. (Nasdaq:AFFX) announced today that the Wellcome Trust Sanger Institute has developed a catalog of structural genomic changes in almost 800 cancer cell lines using the company's Genome-Wide Human SNP Array 6.0. Cancer cell lines are invaluable reagents in analyzing the molecular biology of the disease as well as important tools in developing new healing methods. The core set of cancer cell lines developed by the Cancer Genome Project includes samples from most types of...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.