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Last updated on April 23, 2014 at 21:24 EDT

Latest Copy number variation Stories

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2009-06-18 06:15:00

In the first ever development of its kind, cancer researchers announced on Wednesday that they have discovered a connection between cancer and a type of genetic mutation that results in either missing or redundant pieces of DNA. The genetic defect, known as a copy number variation, was discovered in neuroblastoma cells, a form of pediatric cancer responsible for some 15 percent of all cancer-related deaths in children. A group of researchers at the Children's Hospital of Philadelphia found...

2009-06-03 13:29:00

ALISO VIEJO, Calif., June 3 /PRNewswire/ -- Ambry Genetics is pleased to announce the launch of whole-genome Chromosomal Microarray Analysis (CMA), offering the Ambry CMA: 105K Oligo Array, which is designed to identify chromosomal abnormalities associated with over 270 genetic disorders. In a partnership with Baylor College of Medicine, Ambry is now able to provide one of the most comprehensive, clinically-validated genetic tests available using array comparative genomic hybridization....

2009-04-16 09:55:21

Database provides a key to unlock the causes of illnesses Today - five years after the inception of the DECIPHER database - researchers have published a report that reveals the developing role of the database in revolutionizing both clinical practice and genetic research. The report explores the growing benefits of DECIPHER for researchers, clinicians and patients - highlighting how the data, provided by around 100 centers and shared openly worldwide, can benefit all three groups. DECIPHER -...

2009-02-10 09:13:46

A new study conducted at the Duke Institute for Genome and Sciences Policy suggests schizophrenia is in part caused by large, rare structural changes in DNA commonly called copy number variants, or CNVs. These new findings dismiss two decades of research that pointed to single letter alterations in DNA (SNPs) as possible candidates. Researchers at Duke scanned the genome of schizophrenia patients and healthy controls for SNPs and CNVs. None of the SNPs appeared significant, but several CNVs...

2008-12-16 10:15:16

A newly published genome sequence of a breast cancer cell line  reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report that appears online in the journal Genome Research. "It's like a computer program that has become buggy and transcends into something dangerous," said Dr. Aleksandar Milosavljevic, associate professor in the BCM Human Genome Sequencing Center. "It...

2008-12-16 09:51:03

A newly published genome sequence of a breast cancer cell line reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report that appears online in the journal Genome Research."It's like a computer program that has become buggy and transcends into something dangerous," said Dr. Aleksandar Milosavljevic, associate professor in the BCM Human Genome Sequencing Center. "It makes...

2008-11-12 06:00:20

Illumina, Inc. (NASDAQ:ILMN) today unveiled a new product for DNA Analysis: the Infinium(R) HD Human660W-Quad BeadChip. This four-sample BeadChip features 2.6 million genetics markers and was developed in collaboration with The Centre for Applied Genomics at the Hospital for Sick Children in Toronto, Canada and the Wellcome Trust Sanger Institute in the United Kingdom. The Human660W-Quad BeadChip builds on the content from Illumina's HumanHap550+ BeadChip to target over 5,000 regions in the...

2008-09-25 09:00:54

Affymetrix Inc. (Nasdaq:AFFX) announced today that the Wellcome Trust Sanger Institute has developed a catalog of structural genomic changes in almost 800 cancer cell lines using the company's Genome-Wide Human SNP Array 6.0. Cancer cell lines are invaluable reagents in analyzing the molecular biology of the disease as well as important tools in developing new healing methods. The core set of cancer cell lines developed by the Cancer Genome Project includes samples from most types of...

2008-08-13 09:01:15

Affymetrix Inc. (Nasdaq:AFFX) announced today that researchers around the world have used the Affymetrix Genome-Wide Human SNP Arrays 5.0 and 6.0 to uncover important links between copy number variations (CNVs) and schizophrenia. Researchers from the United States, Europe and Asia published their findings in recent issues of Nature and Nature Genetics. Schizophrenia is a chronic and disabling disorder that affects 2.4 million Americans alone. Even with the best treatments currently...

2008-07-30 15:01:17

REYKJAVIK, Iceland, July 30 /PRNewswire-FirstCall/ -- In a major paper published today in the online edition of the journal Nature, scientists from deCODE genetics and the University of Iceland, along with academic colleagues from the deCODE-led European SGENE consortium, China and the United States, report the discovery of three rare deletions in the human genome that confer risk of schizophrenia. Such deletions are gaps in the normal sequence of the genome that can arise spontaneously...