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Latest CRISPR Stories

2014-04-30 23:08:10

OriGene Technologies, the industry’s largest supplier of gene-centric research tools, launches a new product line of gene-knockout kits using CRISPR technologies. The new products provide a complete solution for researchers to knock out a human gene at the chromosomal level. Rockville, MD (PRWEB) April 30, 2014 OriGene Technologies (Rockville, MD), the industry’s largest supplier of gene-centric research tools, launches a new product line of gene-knockout kits using CRISPR...

2014-04-28 10:17:33

A next-generation genome editing system developed by Massachusetts General Hospital (MGH) investigators substantially decreases the risk of producing unwanted, off-target gene mutations. In a paper receiving online publication in Nature Biotechnology, the researchers report a new CRISPR-based RNA-guided nuclease technology that uses two guide RNAs, significantly reducing the chance of cutting through DNA strands at mismatched sites. "This system combines the ease of use of the widely...

2014-04-08 10:58:47

New insights into a surprisingly flexible immune system present in bacteria for combating viruses and other foreign DNA invaders have been revealed by researchers from New Zealand's University of Otago and the Netherlands. A team led by Dr Peter Fineran of the Department of Microbiology and Immunology are studying the genetic basis of adaptive immunity in bacteria that cause potato 'soft rot' and in E. coli bacteria. Through their recent collaboration they have found that these bacterial...

2014-03-04 23:24:07

The revolutionary NickaseNinja™ combines a tandem pair of gRNAs in a single vector. Menlo Park, CA (PRWEB) March 04, 2014 DNA2.0 today announced the release of a set of CRISPR/Cas9 tools for genome editing and engineering. At the heart of DNA2.0’s CRISPR toolset is the revolutionary NickaseNinja system, which offers the high fidelity editing of Cas9 nickase plus guide RNA (gRNA) pairs, in a convenient single-vector format. By co-expressing two guide RNAs using dual RNA polymerase...

2014-02-25 00:21:09

Medal recognizes work studying RNA BETHESDA, Md., Feb. 25, 2014 /PRNewswire/ -- The Foundation for the National Institutes of Health (FNIH) has selected Jennifer Doudna, Ph.D., a Professor from the University of California, Berkeley, as the second winner of its Lurie Prize in the Biomedical Sciences. Doudna, a Howard Hughes Investigator and Professor of Biochemistry, Biophysics and Structural Biology, will be presented the Lurie Prize medal and a $100,000 honorarium on May 20 in...

2014-02-07 12:52:46

Berkeley Researchers Show Expanded Role for Guide RNA in Cas9 Interactions with DNA The potential is there for bacteria and other microbes to be genetically engineered to perform a cornucopia of valuable goods and services, from the production of safer, more effective medicines and clean, green, sustainable fuels, to the clean-up and restoration of our air, water and land. Cells from eukaryotic organisms can also be modified for research or to fight disease. To achieve these and other...

Precise Gene Modification In Monkeys Paves Way For Valuable Human Disease Models
2014-01-30 15:58:45

Cell Press Monkeys are important for modeling diseases because of their close similarities to humans, but past efforts to precisely modify genes in primates have failed. In a study published by Cell Press January 30th in the journal Cell, researchers achieved precise gene modification in monkeys for the first time using an efficient and reliable approach known as the CRISPR/Cas9 system. The study opens promising new avenues for the development of more effective treatments for a range of...

2014-01-27 13:30:39

A simple adjustment to a powerful gene-editing tool may be able to improve its specificity. In a report receiving advance online publication in Nature Biotechnology, Massachusetts General Hospital (MGH) investigators describe how adjusting the length of the the guide RNA (gRNA) component of the synthetic enzymes called CRISPR-Cas RNA-guided nucleases (RGNs) can substantially reduce the occurrence of DNA mutations at sites other than the intended target, a limitation the team had previously...

2013-12-24 13:35:52

Genetic screening identifies genes driving resistance with a guide RNA library Researchers have developed a method to create a comprehensive library of mutations across all genes in the mouse genome. This library can be used to examine the role of every gene in different cell types. CRISPR technology uses the DNA-cutting enzyme Cas9, with the help of a guide RNA sequence, to find and modify genetic targets. Scientists can easily engineer multiple new guide RNAs using standard molecular...

Technique Accelerates Gene Discovery
2013-12-13 08:05:12

redOrbit Staff & Wire Reports - Your Universe Online Researchers working to decipher the role of genes since the completion of the Human Genome Project may see their efforts accelerated by a new approach that lets them permanently and selectively delete genes from a cell's DNA. The new system, known as CRISPR, was developed by researchers at MIT, the Broad Institute, and the Whitehead Institute, and should allow scientists to study the entire genome at once. In two new papers...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.