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Latest Cryptococcosis Stories

2014-06-12 23:02:20

Fungal Protein Found to Cross Blood-brain Barrier (PRWEB) June 12, 2014 In a remarkable series of experiments on a fungus that causes cryptococcal meningitis, a deadly infection of the membranes that cover the spinal cord and brain, investigators at UC Davis have isolated a protein that appears to be responsible for the fungus’ ability to cross from the bloodstream into the brain. The discovery — published online June 3 in mBio, the open-access, peer-reviewed journal of the American...

Deadly Human Pathogen Cryptococcus Fully Sequenced
2014-04-18 13:05:19

By Marla Vacek Broadfoot, Duke University Ten-year effort yields map for finding weaknesses in the fungus Within each strand of DNA lies the blueprint for building an organism, along with the keys to its evolution and survival. These genetic instructions can give valuable insight into why pathogens like Cryptococcus neoformans -- a fungus responsible for a million cases of pneumonia and meningitis every year -- are so malleable and dangerous. Now researchers have sequenced the...

2014-02-11 10:53:30

Tamoxifen, a drug currently used to treat breast cancer, also kills a fungus that causes a deadly brain infection in immunocompromised patients. The findings, which could lead to new treatments for a disease that kills more HIV/AIDS patients than tuberculosis, appear in mBio®, the online open-access journal of the American Society for Microbiology (ASM.) "This work sets the stage for additional animal studies to see if tamoxifen can be used as a drug in people and will allow us to design...

2013-08-27 12:35:20

HIV-infected people who carry a gene for a specific protein face a 20-fold greater risk of contracting cryptococcal disease, according to a study published in mBio®, the online open-access journal of the American Society for Microbiology. Cryptococcus neoformans is the most common cause of fungal meningitis among HIV-infected individuals. While the disease is a risk for everyone with HIV who has a very low level of CD4+ T cells, researchers have discovered that those with the gene for the...

2012-09-26 13:23:07

The most cost-effective treatment for cryptococcal meningitis (a serious infection of the brain membranes, usually in people with AIDS or other immune system deficiencies) is different to that currently recommended by the World Health Organization (WHO), warranting a review of policy, according to the findings of a study published in this week's PLOS Medicine. Researchers from Makerere University in Kampala, Uganda, and from the University of Minnesota in the US found that a short (7-day)...

2012-07-26 01:15:05

New research conducted by biologists at Texas A&M University suggests that ZOLOFT®, one of the most widely prescribed antidepressants in the world, also packs a potential preventative bonus – potent mechanisms capable of inhibiting deadly fungal infections. The findings are the result of a two-year investigation by Xiaorong Lin, assistant professor of biology, and Matthew S. Sachs, professor of biology, involving sertraline hydrocholoride (ZOLOFT) and its effects on...

2011-09-02 11:44:03

Most AIDS patients, when diagnosed with a fungal infection known simply as cryptococcosis, are assumed to have an infection with Cryptococcus neoformans, but a recent study from Duke University Medical Center suggests that a sibling species, Cryptococcus gattii, is a more common cause than was previously known. The difference between these strains could make a difference in treatment, clinical course, and outcome, said Joseph Heitman, M.D., Ph.D., senior author of the study and chair of...

2011-05-03 13:43:41

New research has shed light on the origins of a fungal infection which is one of the major causes of death from AIDS-related illnesses. The study, published today in the journal PLoS Pathogens, funded by the Wellcome Trust and the BBSRC, shows how the more virulent forms of Cryptococcus neoformans evolved and spread out of Africa and into Asia. Cryptococcus neoformans is a species of often highly aggressive fungi. One particular strain of the fungus "“ known as Cryptococcus neoformas...

2010-12-22 19:07:29

A study in this week's PLoS Medicine suggests that AIDS patients with cryptococcal meningitis who start HIV therapy are predisposed to immune reconstitution inflammatory syndrome (IRIS) "” an exaggerated inflammatory immune response that kills up to one-third of affected people "” if they have biomarkers (biochemicals) in their blood showing evidence of a damaged immune system that is not capable of clearing the fungal infection. David Boulware and Paul Bohjanen from the...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'kardia,' heart.
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