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Latest Cyclin-dependent kinase Stories

2010-02-09 15:22:11

M. D. Anderson researchers find better way to predict prognosis in patients treated with aromatase inhibitors; research also suggests a potential means of circumventing drug resistance Overexpression of low-molecular-weight (LMW-E) forms of the protein cyclin E renders the aromatase inhibitor letrozole ineffective among women with estrogen-receptor-positive (ER+) breast cancers, researchers from The University of Texas M. D. Anderson Cancer Center report in Clinical Cancer Research. The M. D....

2009-08-17 13:39:34

Scientists at Dana-Farber Cancer Institute have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing themselves.The findings being reported in the Aug. 14 issue of Molecular Cell help explain the promising results being seen in clinical trials of compounds that force cancer cells with genetic damage to self-destruct instead of "resting" while their DNA undergoes...

2009-05-13 08:00:00

NERVIANO, Italy, May 13 /PRNewswire/ -- The FDA has approved an Investigational New Drug (IND) application by Nerviano Medical Sciences to begin a phase I clinical study with its selective PLK-1 small molecule inhibitor for the treatment of cancer. PLK-1 is a mitotic kinase required for the proliferation of cancer cells. This new compound is orally bioavailable, highly efficient and well tolerated in preclinical models of cancer after repeated dosing. This unique inhibitor adds another...

2009-01-16 10:53:01

Researchers at the University of Pittsburgh School of Medicine, funded by JDRF, have discovered that adult beta cells have the ability to replicate with the help of a protein known as cdk6. This research was led by Andrew F. Stewart, M.D., a Professor of Medicine and Chief of the Division of Endocrinology and Metabolism at the University of Pittsburgh School of Medicine. The complete findings of this discovery can be found in the early online version of Diabetes."Most scientists thought that...

2008-08-27 09:00:31

By Liu, Jingjing Zhang, Yiyue; Qin, Genji; Tsuge, Tomohiko; Sakaguchi, Norihiro; Luo, Guo; Sun, Kangtai; Shi, Dongqiao; Aki, Shiori; Zheng, Nuoyan; Aoyama, Takashi; Oka, Atsuhiro; Yang, Weicai; Umeda, Masaaki; Xie, Qi; Gu, Hongya; Qu, Li-Jia Following meiosis, plant gametophytes develop through two or three rounds of mitosis. Although the ontogeny of gametophyte development has been defined in Arabidopsis thaliana, the molecular mechanisms regulating mitotic cell cycle progression are not...

2008-07-21 12:01:26

Sound Pharmaceuticals has received a R&D contract award from the Office of Naval Research for approximately $1.6 million to optimize its lead drug candidate for hearing regeneration. Sound Pharmaceuticals has developed a proprietary technology for regenerating auditory sensory cells within the inner ear of mammals involving p27Kip1, a cyclin dependent kinase inhibitor or CKI. In 2005, the Office of Naval Research began funding this hearing regeneration project. This new funding brings...

2008-07-14 09:00:14

Cyclacel Pharmaceuticals, Inc. (NASDAQ:CYCC, NASDAQ:CYCCP) announced the publication of a study conducted by Cyclacel scientists showing synergistic activity between its investigational therapy seliciclib and multiple epidermal growth factor receptor (EGFR) inhibitors, including erlotinib (Tarceva(R)) in models of non-small cell lung cancer and the HER2 targeting agent, trastuzumab (Herceptin(R)) in models of breast cancer. These preclinical results were published in the July issue of the...


Word of the Day
attercop
  • A spider.
  • Figuratively, a peevish, testy, ill-natured person.
'Attercop' comes from the Old English 'atorcoppe,' where 'atter' means 'poison, venom' and‎ 'cop' means 'spider.' 'Coppa' is a derivative of 'cop,' top, summit, round head, or 'copp,' cup, vessel, which refers to 'the supposed venomous properties of spiders,' says the OED. 'Copp' is still found in the word 'cobweb.'
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