Latest Cyclodextrin Stories
LISBON, Portugal, April 3, 2013 /PRNewswire/ -- Hovione today announced a co-promotion and collaboration agreement with Ligand to provide Hovione's customers efficient access to Captisol(R) technology. Captisol, a chemically modified cyclodextrin, is proven to improve the solubility and stability of drugs and is currently used in six marketed products. Hovione offers innovative particle engineering technologies to improve the solubility of modern drugs. The agreement...
A cross-disciplinary team of researchers at the University of Maryland has designed a molecular container that can hold drug molecules and increase their solubility, in one case up to nearly 3000 times. Their discovery opens the possibility of rehabilitating drug candidates that were insufficiently soluble. It also offers an opportunity to improve successful drugs that could be made even better with better solubility. The team's innovative findings were recently published in a study in...
Biocides turn out to be less toxic for the environment if they are subjected to microencapsulation, due to the fact that this process forms shell(s) for the substance. This is the conclusion of chemist Ms Mariluz Alonso in a thesis defended at the University of the Basque Country (UPV/EHU). In this research, she chose a number of biocides and other complementary substances, seeking a micro-encapsulation which, besides being compatible with the environment, is more soluble in water, more...
A little bitter with a little sweet, in the form of a nano-complex dietary supplement taken before meals, can result in a substantial reduction of fat and sugar absorption in the body, Hebrew University of Jerusalem and Harvard University researchers have found.The researchers previously showed that naringenin, the molecule responsible for the bitter taste in grapefruits, could potentially be used in the treatment of diabetes, arteriosclerosis and hyper-metabolism.However, the absorption of...
Vitamins and medications may one day take rides on starch compounds creating stable vitamin-enriched ingredients and cheaper controlled-release drugs, according to Penn State food scientists.The technique may offer drug and food companies a less expensive, more environmentally friendly alternative in creating, among other products, medications and food supplements.In a series of experiments, researchers formed pockets with corn starch and a fatty acid ester to carry oil soluble vitamins, such...
University of Illinois scientists have learned to mask the bitterness of ginseng, a common ingredient of energy drinks."Consumers like to see ginseng on a product's ingredient list because studies show that it improves memory, enhances libido and sexual performance, boosts immunity, and alleviates diabetes. But the very compounds that make ginseng good for you also make it taste bitter," said Soo-Yeun Lee, a U of I associate professor of food science and human nutrition.In an...
Compounds made from renewable materials could be used for gas storage, food technologiesSugar, salt, alcohol and a little serendipity led a Northwestern University research team to discover a new class of nanostructures that could be used for gas storage and food and medical technologies. And the compounds are edible.The porous crystals are the first known all-natural metal-organic frameworks (MOFs) that are simple to make. Most other MOFs are made from petroleum-based ingredients, but the...
Calando Pharmaceuticals, Inc., a majority owned subsidiary of Arrowhead Research Corporation (NASDAQ:ARWR), announced today that it has initiated a Phase II clinical trial in the United States evaluating the safety and efficacy of its drug candidate, IT-101 in patients with platinum-sensitive ovarian cancer. The study is open for enrollment. Previous work with IT-101 suggests that twice monthly "maintenance doses" of IT-101 given after the patient's standard chemotherapy may have minimal...
