Latest Cyclophilin Stories

2010-01-20 18:22:37

Researchers at the National Institutes of Health and other institutions have discovered the third in a sequence of genes that accounts for previously unexplained forms of osteogenesis imperfecta (OI), a genetic condition that weakens bones, results in frequent fractures and is sometimes fatal. The newly identified gene contains the information needed to make the protein Cyclophilin B. This protein is part of a complex of three proteins that modifies collagen, folding it into a precise...

2009-09-09 09:09:56

In 2004, Jeremy Luban and colleagues from the University of Geneva, Switzerland, reported that New World owl monkeys (Aotus genus) make a fusion protein "“ AoT5Cyp "“ that potently blocks HIV-1 infection. The human genome encodes the equivalent of the 2 components of AoT5Cyp (i.e., TRIM5 and cyclophilin A), but humans unfortunately do not make the T5Cyp fusion protein. In their new study in the Journal of Clinical Investigation, Luban et al. have engineered a human HIV-1 inhibitor...

2008-11-03 09:00:40

Drug discovery company SCYNEXIS, Inc. today announced that data from preclinical studies of the Company's lead product candidate for hepatitis C (HCV), SCY-635, will be presented in poster sessions at the 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) being held in San Francisco, October 31-November 4, 2008. SCY-635 represents a new mechanism of action for the treatment of HCV infection and is the first candidate in a novel new class of...

Word of the Day
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.