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Latest CYP2D6 Stories

2010-03-24 14:37:48

Barcelona, Spain -- Recently published research has shown that some breast cancer patients taking tamoxifen may not be getting the full benefit of their treatment because they have also been taking selective serotonin reuptake inhibitors (SSRIs), prescribed drugs that inhibit the effect of an important enzyme. Now researchers have developed a strategy for overcoming this problem, the seventh European Breast Cancer Conference (EBCC7) in Barcelona will hear today (Wednesday). Mr. Sean...

2010-03-17 05:00:00

BOSTON, March 17 /PRNewswire-FirstCall/ -- PAREXEL International Corporation (Nasdaq: PRXL), a leading global biopharmaceutical services provider, today announced that it has completed a large and complex pharmacogenetics-based early phase study. The study was conducted in a healthy volunteer population of poor metabolizers of Cytochrome P450 2D6 (CYP2D6), an important enzyme involved in the metabolism of drugs. The study monitored the QTc interval following administration of a neurological...

2009-10-07 09:44:34

Among women with early stage breast cancer, genetic variation of a certain enzyme appears to be associated with clinical outcomes for women treated with tamoxifen, according to a study in the October 7 issue of JAMA. "Tamoxifen has been the gold standard for the last 25 years for endocrine treatment of breast cancer. It is estimated that the lives of half a million women have been saved with adjuvant [supplemental] tamoxifen therapy," according to background information in the article. The...

2009-05-30 14:45:00

- Several SSRIs more than double risk of cancer recurrence in tamoxifen treated patients - Nearly 30 percent of tamoxifen users take drugs that reduce its effectiveness against breast cancer ORLANDO, Fla., May 30 /PRNewswire-FirstCall/ -- An important new study finds that certain popular antidepressants frequently prescribed to women taking the breast cancer drug tamoxifen more than double the risk of a breast cancer recurrence for those using both medications. The research presented by...

2009-05-30 14:45:00

Popular antidepressants taken with tamoxifen can increase the risk of breast cancer recurrence PHILADELPHIA, May 30 /PRNewswire-USNewswire/ -- A new study found that taking tamoxifen with certain antidepressants more than doubled the risk of breast cancer recurrence in women taking both medications. The antidepressants inhibit an enzyme, CYP2D6, which helps tamoxifen work effectively. (Logo: http://www.newscom.com/cgi-bin/prnh/20090530/DC24767LOGO) The study was conducted by...

2008-10-30 12:00:21

SEATTLE, Oct. 30 /PRNewswire/ -- Nearly one third of breast cancer patients prescribed tamoxifen currently fail treatment. According to the National Foundation for Cancer Research (NFCR), this failure rate can be reduced to less than ten percent, saving 20,000 lives each year, by having patients take a simple DNA test and properly managing their medications. Recent research shows that tamoxifen has to be activated into endoxifen by the liver enzyme CYP2D6. Endoxifen is the medicine that...

2006-01-12 22:30:00

By Will Boggs, MD NEW YORK -- The gene for an enzyme called cytochrome P450 2D6 (CYP2D6) influences how well the breast cancer drug tamoxifen works and whether hot flashes are likely to occur, according to a report in the Journal of Clinical Oncology. "CYP2D6 appears to be critically important for tamoxifen's anti-cancer effect," Dr. Matthew P. Goetz from Mayo Clinic College of Medicine, Rochester, Minnesota told Reuters Health. Goetz and colleagues previously observed that CYP2D6 is needed...


Word of the Day
Cthulhu
  • A gigantic fictional humanoid alien god being described with a head resembling an octopus and dragon wings and claws, around whom an insane cult developed.
  • Pertaining to the mythos of Cthulhu and additional otherworldly beings created by H. P. Lovecraft or inspired by his writings and imitators.
This word was invented in 1926 by H.P. Lovecraft for his short story, 'The Call of Cthulhu.' 'Cthulhu' may be based on the word 'chthonic,' which in Greek mythology refers to the underworld.
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