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Latest CYP3A4 Stories

2011-12-12 08:00:00

The Online Fruit Magazine Pomology.org has added the category Pomelo to its collection of crops. This section comprises resources to this ancient type of citrus, resembling grapefruits with thick rind, pulp color ranging from yellow to pink and red, but sweeter flesh. (PRWEB) December 12, 2011 Pomology is the science and technology of cultivating and producing fruits. Within this discipline, the Online Fruit Magazine Pomology.org provides a wide range of resources related to temperate,...

2011-08-11 12:31:00

PHILADELPHIA, Aug. 11, 2011 /PRNewswire/ -- Newly-published results from a series of colchicine safety studies provide physicians with the first evidence-based dosing guidance for colchicine when co-administered with certain commonly prescribed drugs, helping doctors and patients avoid serious and potentially life-threatening drug-drug interactions. The study results, published in a paper titled "Evidence Basis of a Novel Colchicine Dose Reduction Algorithm to Predict and Prevent...

2011-03-09 14:07:33

A study from Karolinska Institutet has shown that the body's ability to break down medicines may be closely related to exposure to sunlight, and thus may vary with the seasons. The findings offer a completely new model to explain individual differences in the effects of drugs, and how the surroundings can influence the body's ability to deal with toxins. The study will be published in the scientific journal Drug Metabolism & Disposition and is based on nearly 70,000 analyses from...

2007-06-12 03:00:10

By Masubuchi, Yasuhiro Horie, Toshiharu Cytochrome P450 (P450) enzymes oxidize xenobiotics into chemically reactive metabolites or intermediates as well as into stable metabolites. If the reactivity of the product is very high, it binds to a catalytic site or sites of the enzyme itself and inactivates it. This phenomenon is referred to as mechanism-based inactivation. Many clinically important drugs are mechanism-based inactivators that include macrolide antibiotics, calcium channel...


Word of the Day
jument
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.
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