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Latest Cytochrome P450 Stories

2011-07-25 07:30:00

MONTREAL, July 25, 2011 /PRNewswire/ - Sunshine Biopharma Inc. (OTCBB: SBFM) a development stage pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has completed a study in which the mechanism of clearance of the Company's new drug, Adva-27a, was analyzed using human liver microsomes in vitro.  Clearance refers to the mechanism by which a drug is metabolized and...

2010-11-17 08:45:00

AUSTIN, Texas, Nov. 17, 2010 /PRNewswire-FirstCall/ -- Luminex Corporation (Nasdaq: LMNX), today announced that it has commercially launched its first pharmacogenetic test, the xTAG® CYP2D6 Kit, which recently received 510(k) clearance from the U.S. Food and Drug Administration (FDA). The new test enables a personalized medicine approach to help physicians manage patients for whom they may prescribe certain drugs that are metabolized by the enzyme cytochrome P450 2D6....

2010-11-15 21:32:25

Many plants, including crops, release volatiles in response to insect attack. The chemical compounds can be a defense or can be an aromatic call for help to attract enemies of the attacking insect. Researchers from Virginia Tech, Michigan State University, and Georg-August-University Göttingen have discovered how plants produce the defensive compounds. The research is reported this week in the online early edition of the Proceedings of the National Academy of Sciences. The article,...

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2010-11-13 06:42:23

Future studies of P450 compound I could lead to the more efficient design and creation of drugs Chemical reactions are happening all over the place all the time--on the sun, on the Earth and in our bodies. In many cases, enzymes help make these reactions occur. One family of enzymes, called cytochrome P450s (P450), is important because they help us eliminate toxins. We know P450s are important to life of all kinds because they have been found in animals, plants, fungi and bacteria, but they...

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2010-11-12 08:16:40

For the first time, scientists have been able to "freeze in time" a mysterious process by which a critical enzyme metabolizes drugs and chemicals in food. By recreating this process in the lab, a team of researchers has solved a 40-year-old puzzle about changes in a family of enzymes produced by the liver that break down common drugs such as Tylenol, caffeine, and opiates, as well as nutrients in many foods. The breakthrough discovery may help future researchers develop a wide range of more...

2010-11-04 01:43:35

New radiotracer application reveals features unique to humans; may advance understanding of estrogen-related diseases A study at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory has demonstrated that a molecule "tagged" with a radioactive form of carbon can be used to image aromatase, an enzyme responsible for the production of estrogen, in the human brain. The research, published in the November issue of Synapse, also uncovered that the regions of the brain where...

2010-10-26 14:17:00

VISTA, Calif., Oct. 26 /PRNewswire/ -- AutoGenomics, a leader in providing automated, molecular testing solutions announced today that it has received 510(k) clearance from the U.S. Food and Drug Administration to market its INFINITI® CYP2C19 Assay. The test detects 3 genetic variants, *2, *3, *17, of the CYP450 2C19 gene and is to be used on the company's automated molecular testing platform, the INFINITI® Analyzer. "We are very excited to receive...

2010-10-04 19:34:32

While computer simulations of how the body metabolizes drugs save both time and money, the best results when developing new drugs come from combining such simulations with laboratory experiments, reveals a researcher from the University of Gothenburg. "My research demonstrates the benefits of combining traditional laboratory experiments with computer-based calculation models to understand and explain how the body's various enzymes interact with a drug when breaking it down," says Britta Bonn...

2010-09-30 19:40:51

New research in the FASEB Journal suggests that increasing the level of the P450 protein causes the creation of molecules called EETs, which lower blood pressure If you are one of the millions of Americans with high blood pressure, more help is on the way. That's because a new research study published in the October 2010 print issue of The FASEB Journal (http://www.fasebj.org) shows that a protein, called P450, metabolizes arachidonic acid in our blood vessel walls to create a tiny molecule...

2010-06-22 15:56:28

Researchers have found that increasing certain proteins in the blood vessels of mice, relaxed the vessels, lowering the animal's blood pressure. The study provides new avenues for research that may lead to new treatments for hypertension. "The paper demonstrates that cytochrome P450 plays an important role in the management of high blood pressure, a disease of enormous public health concern," said Darryl Zeldin, M.D., acting clinical director of the National Institute of Environmental Health...


Word of the Day
conjunto
  • A style of popular dance music originating along the border between Texas and Mexico, characterized by the use of accordion, drums, and 12-string bass guitar and traditionally based on polka, waltz, and bolero rhythms.
The word 'conjunto' comes through Spanish, from Latin coniūnctus, past participle of coniungere, to join together; see conjoin