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Latest Cytoskeleton Stories

463b4c74ddfa94a6509807cc948239b71
2009-11-17 09:59:56

In order to effectively fight pathogens, even at remote areas of the human body, immune cells have to move quickly and in a flexible manner Scientists from the Max Planck Institute (MPI) of Biochemistry in Martinsried near Munich, Germany, have now deciphered the mechanism that illustrates how these mobile cells move on diverse surfaces. "Similar to a car, these cells have an engine, a clutch and wheels which provide the necessary friction," explains Michael Sixt, a research group leader at...

2009-10-20 09:28:53

New publication in Molecular Therapy outlines dramatic effects in animals treated with splice switching PPMO, demonstrates promise for treatment of Duchenne muscular dystrophy An exon skipping PPMO has demonstrated dramatic effects in the prevention and treatment of severely affected, dystrophin and utrophin-deficient mice, preventing severe deterioration of the treated animals and extending their lifespan. These findings were published online today in the journal Molecular Therapy and...

2009-10-13 00:00:00

AMSTERDAM, October 13 /PRNewswire-FirstCall/ -- Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, announced today that the European Medicines Agency has granted Orphan Drug Designation to AMT's gene therapy product AMT-080 for the treatment of Duchenne muscular dystrophy. Orphan Drug Designation for Duchenne muscular dystrophy (DMD) entitles AMT to ten year market exclusivity in Europe following marketing approval for AMT-080 if this...

2009-09-14 08:31:11

A network of proteins underlying the plasma membrane keeps epithelial cells in shape and maintains their orderly hexagonal packing in the mouse lens, say Nowak et al. The study will appear in the September 21, 2009 issue of the Journal of Cell Biology (online September 14). Spectrin, F-actin, and associated proteins form a meshwork that supports and shapes the plasma membrane of red blood cells. A similar network underlies the membranes of other cell types, including lens fiber cells:...

aad8948998aa23c1957173ffbcc797651
2009-09-11 07:58:32

Every moment, millions of a body's cells flawlessly divvy up their genes and pinch perfectly in half to form two identical progeny for the replenishment of tissues and organs "” even as they collide, get stuck, and squeeze through infinitesimally small spaces that distort their shapes. Now Johns Hopkins scientists, working with the simplest of organisms, have discovered the molecular sensor that lets cells not only "feel" changes to their neat shapes, but also to remodel themselves back...

7be48c22c84e34c5e0d37b64a7f42f0b1
2009-08-14 10:00:00

Friction is the force that resists the relative motion of two bodies in contact. The same is true on the nanoscale: Molecular motors have to fight the friction created between them and their tracks. However, since the frictional forces acting on such motors had not been measured before, it was not known how they depend on the speed and the direction of motion.Friction Slows Down ProteinsScientists in Dresden at the Biotechnology Center (BIO-TEC) of the Technical University of Dresden and at...

2009-07-21 19:15:00

Cells rely on tiny molecular motors to deliver cargo, such as mRNA and organelles, within the cell. The critical nature of this transport system is evidenced by the fact that disruption of motors by genetic defects leads to fatal diseases in humans. Although investigators have isolated these motor to study their function in a controlled environment outside the cell, it has been difficult for researchers to follow these fascinating molecular transporters in their natural environment, the...

2009-07-15 12:40:00

Understanding how neurons migrate to their proper place during brain development will offer insights into how malfunctions in the machinery cause epilepsy and mental retardation MEMPHIS, Tenn., July 15 /PRNewswire-USNewswire/ -- The molecular machinery that helps brain cells migrate to their correct place in the developing brain has been identified by scientists at St. Jude Children's Research Hospital. The finding offers new insight into the forces that drive brain organization in...

2009-07-15 13:40:00

Understanding how neurons migrate to their proper place during brain development will offer insights into how malfunctions in the machinery cause epilepsy and mental retardationThe molecular machinery that helps brain cells migrate to their correct place in the developing brain has been identified by scientists at St. Jude Children's Research Hospital. The finding offers new insight into the forces that drive brain organization in developing fetuses and children during their first years....

462f7b8b66d8a6bac25d1a6f0b6875dc1
2009-07-13 10:55:00

New study helps explain why it is easy to encode new memories but hard to hold onto themMemories aren't made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories. In the July 13, 2009 issue of the Journal of Cell Biology (www.jcb.org), Rex et al. reveal that LTP's actin reorganization occurs in two stages that are controlled by different pathways, a discovery that helps explain...


Word of the Day
grass-comber
  • A landsman who is making his first voyage at sea; a novice who enters naval service from rural life.
According to the OED, a grass-comber is also 'a sailor's term for one who has been a farm-labourer.'