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Latest Cytoskeleton Stories

Molecular Muscles Inside Cells Help Them Sense, Respond To Their Environments
2013-10-21 07:27:59

Johns Hopkins Medicine Johns Hopkins researchers used suction to learn that individual "molecular muscles" within cells respond to different types of force, a finding that may explain how cells "feel" the environment and appropriately adapt their shapes and activities. A summary of the discovery, published online Oct. 20 in the journal Nature Materials, specifically sheds light on how forces outside of cells are translated into internal signals. A computer model the researchers...

2013-07-29 16:33:05

Crystal structure of a key initiation protein while bound is captured in one of two newly reported studies University of Oregon biochemists have determined how tiny synthetic molecules disrupt an important actin-related molecular machine in cells in one study and, in a second one, the crystal structure of that machine when bound to a natural inhibitor. The accomplishments -- done in the name of fundamental understanding, or basic science -- provide new windows on the complexities of...

New Research Challenges 50 Years Of Muscle Knowledge
2013-07-10 10:54:49

Michael Harper for redOrbit.com - Your Universe Online For the past 50 years, scientists and health professionals have operated with the knowledge that biceps are packed with long ropes of filaments. When the bicep is used to lift a heavy object or flex, these filaments were understood to shorten or contract the muscle and give it its power. A new study from the University of Washington (UW) challenges this notion, saying that while the general idea of filaments contracting is the same,...

2013-06-27 12:39:52

Scientists at the University of East Anglia have made a major advancement in understanding tissue development that has important implications for cancer. Findings published today in the Journal of Cell Science show how the protein EB2 is a key regulator of tube-like structures inside cells and critical for normal tissue development and function. The findings are an important step in the race to find cures for cancers including gut, breast and pancreatic cancer. Microtubules are...

Promise In Duchenne Muscular Dystrophy Shown With Genetic Editing
2013-06-05 08:48:09

Duke University Using a novel genetic 'editing' technique, Duke University biomedical engineers have been able to repair a defect responsible for one of the most common inherited disorders, Duchenne muscular dystrophy, in cell samples from Duchenne patients. Instead of the common gene therapy approach of adding new genetic material to "override" the faulty gene, the Duke scientists have developed a way to change the existing mutated gene responsible for the disorder into a normally...

2013-06-05 08:30:19

Approval clears the way for commencement of beta-site testing of the QL Care(TM) Analyzer in hospitals MISSISSAUGA, Ontario, June 5, 2013 /PRNewswire/ -- CardioGenics Holdings Inc. (OTCBB: CGNH), developer of the ultra-sensitive QL Care(TM) analyzer, an immunoassay Point-Of-Care Analyzer, and other products targeting the In-Vitro-Diagnostics testing market, announced today that it has received approval of its clinical testing protocol from the Institutional Review...

2013-04-30 10:57:44

A team of international researchers led by Northwestern Medicine scientists has identified how a defective protein plays a central role in a rare, lethal childhood disease known as Giant Axonal Neuropathy, or GAN. The finding is reported in the May 2013 Journal of Clinical Investigation. GAN is an extremely rare and untreatable genetic disorder that strikes the central and peripheral nervous systems of young children. Those affected show no symptoms at birth; typically around age three the...

2013-03-21 12:28:17

HACKENSACK, N.J., March 21, 2013 /PRNewswire-USNewswire/ -- Parent Project Muscular Dystrophy (PPMD) has awarded University of Minnesota researcher Dr. Rita Perlingeiro a grant for $220,000 to develop a therapeutic approach for Duchenne muscular dystrophy (Duchenne) using a new type of "adult-derived" stem cell called "induced pluripotent stem cells" or "iPSCs." iPSCs can be created from non-controversial sources like skin, have the ability to multiply indefinitely, and can be coaxed to...

2013-03-14 16:56:01

First-in-class chemical compound might control metastases It´s the spread of the original cancer tumor that kills most people. That´s why cancer researchers vigorously search for drugs that can prevent metastases, the spread of cancer. The research team co-led by Angela Wandinger-Ness, PhD, and Larry Sklar, PhD, at the University of New Mexico Cancer Center has found a chemical compound that appears to control cell migration and adhesion, two important characteristics of...

A New Look At How Plants Sense Gravity
2013-02-04 16:31:22

American Journal of Botany Gravity affects the ecology and evolution of every living organism. In plants, the general response to gravity is well known: their roots respond positively, growing down, into the soil, and their stems respond negatively, growing upward, to reach the sunlight. But how do plants sense gravity and how do they direct or signal their cells to grow in response to it? Although botanists understand a great deal about how this works, a recent article in the recent issue...