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Latest Cytoskeleton Stories

2011-04-16 00:49:21

The proteins that provide cells with a sense of personal space could lead to a therapeutic target for Neurofibromatosis Type 2 (NF2), an inherited cancer disorder, according to researchers at The Wistar Institute. Their findings, which appear in the April 12 issue of the journal Cancer Cell, could have profound implications for NF2 and related cancers, such as mesothelioma. The researchers describe, for the first time, that Merlin, the protein encoded within the NF2 gene interacts with a...

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2011-04-12 11:20:00

X-rays shed new light on the regulation of muscle contraction In a famous experiment first performed more than 220 years ago, Italian physician Luigi Galvani discovered that the muscles of a frog's leg twitch when an electric voltage is applied. An international group of scientists from Italy, the UK and France has now brought this textbook classic into the era of nanoscience. They used a powerful new synchrotron X-ray technique to observe for the first time at the molecular scale how muscle...

2011-03-18 11:22:00

Zebrafish study highlights existing drugs that may help restore muscle in DMD BOSTON, March 18, 2011 /PRNewswire-USNewswire/ -- Armed with a zebrafish model of Duchenne muscular dystrophy (DMD) and a library of 1,200 chemicals already approved for human use, researchers at Children's Hospital Boston have identified a compound that reverses the loss of muscle structure and function associated with DMD, seemingly by compensating for the loss of a critical protein. The discovery, published...

2011-03-17 21:02:25

Novel mechanistic approach to directly modulating muscle contractility may represent a promising strategy to treat systolic heart failure Cytokinetics, Incorporated (Nasdaq: CYTK) announced today the publication of preclinical research in the March 18, 2011 issue of the journal Science regarding the activation of cardiac myosin by an investigational drug candidate, omecamtiv mecarbil, and the potential therapeutic role that this novel mechanism may play for patients with systolic heart...

2011-03-07 12:23:17

Presentation today at Biophysical Society Meeting in Baltimore From grinding heavy metal to soothing ocean waves, the sounds we hear are all perceptible thanks to the vibrations felt by tiny molecular motors in the hair cells of the inner ear. Researchers at the University of Pennsylvania School of Medicine have now identified the mechanism by which a single amino acid change can disrupt the normal functioning of one of the critical components of that physiology -- a molecular motor protein...

2011-03-06 23:59:00

AMSTERDAM, March 7, 2011 /PRNewswire-FirstCall/ -- Amsterdam Molecular Therapeutics (AMT) (Euronext: AMT), a leader in the field of human gene therapy, announced today that the Duchenne Parent Project, based in the Netherlands, has awarded AMT a grant of EUR 145,000 to support the development of AMT-080, AMT's gene therapy for Duchenne Muscular Dystrophy (DMD). DMD is a severe, fatal disease affecting young children, almost exclusively boys, characterized by progressive muscle...

2011-03-02 13:53:14

Model system delivers vital clues on the aging processes of elastic polymers Many materials, when observed over a sufficiently long period of time, show changes in their mechanical properties. The exact course of these developments depends on the underlying microscopic mechanisms. However, the microscopic structure and the complexity of the systems make direct observation extremely difficult. That is why a team led by Professor Andreas Bausch from the Chair of Cellular Biophysics resorted to...

2011-02-15 19:44:22

New research sheds light on the interaction between the semi-flexible protein tropomyosin and actin thin filaments. The study, published by Cell Press on February 15th in the Biophysical Journal, provides the first detailed atomic model of tropomyosin bound to actin and significantly advances the understanding of the dynamic relationship between these key cellular proteins. Tropomyosin is a long protein that associates with actin, a highly conserved thin filament protein found in organisms...

2011-01-10 14:12:53

Research by engineers and cancer biologists at Virginia Tech indicate that using specific silicon microdevices might provide a new way to screen breast cancer cells' ability to metastasize. An image of their work provided to Biomaterials was selected as one of the 12 best biomaterials-related images published in the journal's 2010 catalogue. http://www.elsevierscitech.com/pdfs/Biomaterials_2010.pdf The Virginia Tech researchers are: Masoud Agah, director of Virginia Tech's...

2010-12-27 20:41:24

A novel potential therapy based on a natural human protein significantly slows muscle damage and improves function in mice who have the same genetic mutation as boys with the most common form of muscular dystrophy, according to a paper published online Dec. 27 in the Proceedings of the National Academy of Sciences. Duchenne Muscular Dystrophy is a fatal genetic mutation in about one of every 3,500 boys. They are unable to produce a protein called dystrophin that keeps muscles strong. By eight...


Word of the Day
virgule
  • A punctuation mark (/) used to separate related items of information.
  • A little rod; a twig.
This word comes from the Late Latin 'virgula,' accentual mark, a diminutive of 'virga,' rod.
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