Latest Cytotoxic T cell Stories

2011-01-20 11:40:00

Researchers have for the first time mapped the complex choreography used by the immune system's T cells to recognize pathogens while avoiding attacks on the body's own cells. The researchers found that T cell receptors "“ molecules located on the surface of the T cell "“ first bind with the antigen on the pathogen-invaded cell. That initiates a signaling process which leads a co-receptor on the T cell to also bind with the molecule that presents the antigen, amplifying the effect....

2010-11-19 12:56:42

Natural killer cells are major weapons in the body's immune system. They keep the body healthy by knocking off tumors and cells infected with viruses, bombarding them with tiny lethal pellets. But natural killer cells are powerless against HIV, a fact that has bedeviled science for over 20 years. Now, researchers at Rush University Medical Center have discovered the reason why. The study, posted online this week in the prestigious peer-reviewed journal Cell Host & Microbe, marks the...

2010-04-29 13:21:45

Limited success in modeling the behavior of the complex, unusual and unpredictable HIV virus has slowed efforts to develop an effective vaccine to prevent AIDS. A new improved modeling system, developed by Chinese researchers, which attempts to incorporate more of the virus' random behavioral dynamics, suggests that a particular type of T cell could be useful in the development of an AIDS vaccine. New research published today, Thursday 29 April, in New Journal of Physics (co-owned by the...

2009-12-02 11:14:40

Treatment for a number of cancers and other medical conditions is transplantation with bone marrow from a genetically nonidentical individual (a process known as allogeneic bone marrow transplantation [allo-BMT]). The treatment often causes an extended period of immune deficiency, resulting in susceptibility to infections and recurrence of cancers. Damage to the thymus (the part of the body where immune cells known as T cells develop) elicited by T cells from the donor bone marrow (a medical...

2009-11-03 07:39:54

May lead to more effective, precisely targeted therapies for cancers and infections The immune system's T cells have the unique responsibilities of being both jury and executioner. They examine other cells for signs of disease, including cancers or infections, and, if such evidence is found, rid them from the body. Precisely how T cells shift so swiftly from one role to another, however, has been a mystery. In a new study, investigators at Dana-Farber Cancer Institute, Harvard Medical School,...

2009-09-15 08:01:30

X-linked lymphoproliferative disease (XLP) is a rare inherited immunodeficiency most commonly caused by deficiency in the protein SAP. Following infection with the common virus that causes infectious mononucleosis (also known as mono or glandular fever), boys with XLP often develop an extreme, usually fatal, accumulation of activated immune cells known as cytotoxic T lymphocytes; but the mechanistic link between this and SAP deficiency has not been determined. However, Michael Lenardo and...

2009-08-31 09:36:30

Viruses have numerous tricks for dodging the immune system. In the September 7, 2009 issue of the Journal of Cell Biology, Stagg et al. reveal a key detail in one of these stratagems, identifying a protein that enables cytoÂmegalovirus to shut down an antiviral defense (online August 31).Cytomegalovirus, which most people contract at some point in their lives, eludes immune system surveillance by targeting the protein MHC I. When we're sick, MHC I captures bits of viral proteins...

2009-02-02 17:21:56

By using OP9-DL1 cells as a support system, researchers can study the differentiation of embryonic stem cells into mature components of the immune system. This month's issue of Cold Spring Harbor Protocols (www.cshprotocols.org/TOCs/toc2_09.dtl) features a set of methods from Juan Carlos Zúñiga-Pflcker's laboratory at the University of Toronto (http://www.immunology.utoronto.ca/faculty/directory/zunigapflucker.htm) detailing "The OP9-DL1 System:...

Word of the Day
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.