Latest Cytotoxicity Stories

PLANTATION, Fla. and LEXINGTON, Ky., April 25, 2013 /PRNewswire/ -- Goodwin Biotechnology, Inc. (GBI) and Coldstream Laboratories, Inc. have established a collaboration for developing and manufacturing high-potency, highly cytotoxic materials (e.g., small molecules, protein toxins, cytotoxic antibody drug conjugates, and other bioconjugates). "Over the last 20 years, GBI has offered cell culture and purification process development, scale-up, GLP manufacturing and cGMP manufacturing...

Frozen, Thaw-and-Use Cells Reduce Variability Compared to PBMCs and NK Cells Madison, WI (PRWEB) October 10, 2012 Promega Corporation announces the introduction of a novel bioluminescent assay for the quantification of Fc effector function of antibody-based molecules in the development and manufacture of biologic drugs. The assay is ADCC mechanism of action (MOA)-based and features frozen, thaw-and-use effector cells, and optimized reagents and protocol to perform a reporter-based ADCC...

In vitro tests show EnerChip™ batteries are ideal for implanted medical devices Minneapolis, MN (PRWEB) July 31, 2012 Cymbet Corporation announced today the successful results of in vitro biocompatibility feasibility studies that were conducted to evaluate the cytotoxicity potential of the EnerChip™ Rechargeable Solid State Battery. EnerChip bare die battery samples were gamma sterilized and evaluated using two in vitro test methods for cytotoxicity: a) Medium Eluate Method (MEM) -1X...

The new drugs would be more effective and with fewer side effects Researchers from the Research Programme in Biomedical Informatics (GRIB) from the IMIM (Hospital del Mar Research Institute) and the Pompeu Fabra University (UPF) have identified 115 proteins in silico (via computer simulation) that could be highly relevant to treat colon-rectal cancer, since they would make it possible to define the strategy to design new generation anti-cancer drugs. During the last years, it has been...

MONROVIA, Calif., April 19, 2012 /PRNewswire/ -- Xencor, Inc. announced today that the Company received a milestone payment under an antibody optimization collaboration agreement with CSL Limited. The payment was triggered by filing of an investigational new drug application with the FDA for a novel monoclonal antibody that was optimized using Xencor's XmAb® antibody engineering technology. This is the first XmAb candidate to move into human clinical testing under the agreement...

MONROVIA, Calif., April 4, 2012 /PRNewswire/ -- Xencor, Inc. announced today that the Company received a milestone payment under a technology license agreement with Boehringer Ingelheim. The payment was triggered by a regulatory submission to begin Phase 1 clinical trials of a novel monoclonal antibody that was optimized using Xencor's XmAb® antibody engineering technology. This is the second XmAb candidate entering human clinical trials under the agreement with Boehringer...

PENZBERG, Germany, March 28, 2012 /PRNewswire/ -- Roche's xCELLigence RTCA [https://www.roche-applied-science.com/sis/xcelligence/index.jsp?&id=xcect_000000 ] System is being used in the European Union's SEURAT (Safety Evaluation Ultimately Replacing Animal Testing) initiative to run five years from 2011 to 2016. As of 2013, animal experiments are no longer permitted for use in toxicology testing in the cosmetic industry. Significant progress has been made in recent years...

MACCLESFIELD, England, December 7, 2010 /PRNewswire-FirstCall/ -- Cyprotex (LSE:CRX), the preclinical ADME Tox services company, announces the successful cross validation of the CellCiphr(TM) cytotoxicity panels and their official relaunch as a Cyprotex service. These panels detect toxicological markers in a range of cell models (HepG2, primary hepatocytes, and cardiomyocytes). This cross validation follows the acquisition of the CellCiphr(TM) technology from Cellumen, Inc., in August...

SOUTH SAN FRANCISCO, Calif., July 8 /PRNewswire/ -- Calithera Biosciences, a company developing novel oncology therapeutics, today announced the completion of a Series A financing totaling $40 million. Morgenthaler Ventures led the financing with U.S. Venture Partners, Advanced Technology Ventures, Delphi Ventures and Mission Bay Capital also participating in the round. The capital will be used to support the company's pioneering efforts to develop activators of caspases, the proteases...

PRINCETON, N.J., June 23 /PRNewswire/ -- BioWa, Inc. announced today that it has entered into two agreements with GlaxoSmithKline (GSK). BioWa and GSK have amended their existing 2007 arrangement in order to provide GSK with extended access to BioWa's POTELLIGENT® Technology platform for the research, development and commercialization of their antibody therapeutics with enhanced antibody-dependent cellular cytotoxicity (ADCC). The second license agreement provides GSK with access to...