Latest Dengue shock syndrome Stories

A Phase 1b clinical trial to evaluate Celgosivir as a treatment against Dengue Fever has opened for enrolment at the Singapore General Hospital. Dalton Pharma Services has successfully completed a comprehensive drug development program for the CELADEN trial, which included Celgosivir process development, cGMP API and capsule manufacturing in support of Duke-NUS’s translational clinical research program. Toronto, Ontario (PRWEB) July 24, 2012 A clinical trial to treat dengue fever with a...

Brett Smith for redOrbit.com - Your Universe Online Florida residents are voicing their opposition to the release of genetically modified (GM) mosquitoes by a British pest control company; despite the fact that the pesky critters were engineered to impede the spread of dengue fever. Dengue Fever, which comes from a virus spread by the bite of an infected mosquito, was first recognized in the 1950s, yet has become a leading cause of hospitalization and death among children in tropical...

Researchers at the Johns Hopkins Bloomberg School of Public Health have found evidence of a role for neighborhood immunity in determining risk of dengue infection. While it is established that immunity can be an important factor in the large-scale distribution of disease, this study demonstrates that local variation at spatial scales of just a few hundred meters can significantly alter the risk of infection, even in a highly mobile and dense urban population with significant immunity....

PANAMA CITY, Panama, May 21, 2012 /PRNewswire/ -- International scientific and government experts held a forum on 16 May 2012 to discuss the potential use of Oxitec's genetically modified Aedes aegypti mosquitoes as a tool to combat Dengue Fever in Panama. The independent forum was co-organised by the Smithsonian Tropical Research Institute (STRI), The Gorgas Memorial Institute for Health Studies and the University of Panama. This brought together national and regional...

Researchers calculate surveillance and prevention of mosquito-borne disease known as 'break-bone' fever could save $5 for every $1 invested As public health experts warn that the spread of dengue fever could prove more costly globally and cause more sickness than even malaria, a new report published today in the May issue of the American Journal of Tropical Medicine and Hygiene finds each year dengue is inflicting a US$ 37.8 million burden on Puerto Rico and that every $1 invested in...

Changes promote blood-feeding behavior and virus transmission Mosquitoes infected with dengue virus experience an array of changes in the activity of genes and associated functions of their salivary glands, and these changes may lead to increased virus transmission, according to a recent study led by George Dimopoulos, Ph.D., of the Malaria Research Institute and Bloomberg School of Public Health at Johns Hopkins University. Some of these changes involve the mosquito's immune system and...

Researchers at the Johns Hopkins Bloomberg School of Public Health have, for the first time, shown that infection with dengue virus turns on mosquito genes that makes them hungrier and better feeders, and therefore possibly more likely to spread the disease to humans. Specifically, they found that dengue virus infection of the mosquito's salivary gland triggered a response that involved genes of the insect's immune system, feeding behavior and the mosquito's ability to sense odors. The...

Researchers have identified enzymes and biochemical compounds called lipids that are targeted and modified by the dengue virus during infection, suggesting a potential new approach to control the aggressive mosquito-borne pathogen. Their results appear March 22nd in the Open Access Journal PLoS Pathogens. Findings also suggest that medications used to treat high cholesterol and other lipid-related conditions might also inhibit dengue's replication and could represent a potential new...

Protein biomarkers allow early detection and could greatly reduce mortality Researchers at the University of Texas Medical Branch have developed the first accurate predictive model to differentiate between dengue fever (DF) and its more severe form, dengue hemorrhagic fever (DHF). The breakthrough, which could vastly reduce the disease's mortality rate, was reported in related papers in The American Journal of Tropical Medicine and Hygiene and Clinical and Translational Science. These...

OXFORD, England, February 13, 2012 /PRNewswire/ -- Oxitec Ltd, a British company pioneering a new approach to combating dengue fever, announced today that it has secured GBP8 million of new investment. The investment will finance further trials of the Oxitec Control Programme, designed to reduce populations of the dengue mosquito in communities hardest hit by the disease. The Oxitec solution harnesses advanced genetics to create 'sterile' male insects. The company has...