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Latest Denise Faustman Stories

Tuberculosis Vaccine Possibly Reverse Diabetes
2012-08-10 09:09:08

Connie K. Ho for redOrbit.com — Your Universe Online Researchers recently discovered that a tuberculosis vaccine could decrease autoimmunity and boost insulin production in patients who have long-term Type 1 diabetes. The vaccine has been utilized for the past 90 years and scientists believe that it could help eliminate the necessity of having insulin injections for patients with Type 1 diabetes. With Type 1 diabetes, patients normally need to inject insulin on a daily basis so...

2012-08-09 10:28:55

Treatment with generic vaccine kills autoimmune cells, temporarily restoring insulin production A phase I clinical trial has confirmed that use of a generic vaccine to raise levels of an immune system modulator can cause the death of autoimmune cells targeting the insulin-secreting cells of the pancreas and temporarily restore insulin secretion in human patients with type 1 diabetes. Results of the study — led by Denise Faustman, MD, PhD, director of the Massachusetts General...

2012-03-23 09:41:10

Study provides important clue in type 1 diabetes; could help scientists identify and validate potential drug targets to alleviate ER stress and preserve beta cell mass in T1D In type 1 diabetes (T1D), pancreatic beta cells die from a misguided autoimmune attack, but how and why that happens is still unclear. Now, JDRF-funded scientists from the Indiana University School of Medicine have found that a specific type of cellular stress takes place in pancreatic beta cells before the onset of...

2012-03-06 10:34:04

Understanding why immune cells, called T-cells, attack the body is vital in the war against autoimmune diseases like diabetes. University of Alberta researcher Troy Baldwin is a step closer to understanding why the body's T-cells sometimes attack healthy cells causing autoimmune diseases. Baldwin and graduate student Alex Suen looked at a specific molecule, Bim, which is vital in regulating T-cell death. When they removed Bim they found that the autoreactive T-cells, which are normally...

2012-02-24 06:20:20

(Ivanhoe Newswire) — New research has found that insulin production may persist for decades after the onset of type 1 diabetes. Beta cell functioning also appears to be preserved in some patients years after apparent loss of pancreatic function. "Traditionally, it was thought that beta cell function completely ceased in patients with advanced type 1 diabetes. However, data from this study and others suggest that the pancreas continues to function at some level even decades after the...

2012-02-23 06:21:32

(Ivanhoe Newswire) — New research has found that insulin production may persist for decades after the onset of type 1 diabetes. Beta cell functioning also appears to be preserved in some patients years after apparent loss of pancreatic function. "Traditionally, it was thought that beta cell function completely ceased in patients with advanced type 1 diabetes. However, data from this study and others suggest that the pancreas continues to function at some level even decades after the...

2012-02-21 23:12:34

C-peptide production and beta cell functioning detected decades after disease onset Massachusetts General Hospital (MGH) research has found that insulin production may persist for decades after the onset of type 1 diabetes. Beta cell functioning also appears to be preserved in some patients years after apparent loss of pancreatic function. "Traditionally, it was thought that beta cell function completely ceased in patients with advanced type 1 diabetes. However, data from this study and...

2011-12-02 01:47:29

Cellular movies could greatly enhance search for Type 1 disease interventions A war is being waged in the pancreases of millions of people throughout the world. The siege leads to the development of type 1 diabetes and has been a battlefield largely hidden from view-- until now. Researchers at the La Jolla Institute for Allergy & Immunology have created the first cellular movies showing the destruction underlying type 1 diabetes in real-time in mouse models. This detailed, dynamic view...

2011-06-27 14:15:49

Generic drug reproduces mechanism that reversed diabetes in mice, Phase II trial now underway Promising results of the Phase I clinical trial of the generic drug BCG (bacillus Calmette-Guerin) to treat advanced type I diabetes were announced today at the American Diabetes Association scientific sessions in San Diego. A research team led by Denise Faustman, MD, PhD, director of the Massachusetts General Hospital (MGH) Immunobiology Laboratory is presenting two abstracts (No. 2240-PO and No....

2011-06-06 15:14:05

An experimental cure for Type 1 diabetes has a nearly 80 percent success rate in curing diabetic mice. The results, to be presented Saturday at The Endocrine Society's 93rd Annual Meeting in Boston, offer possible hope of curing a disease that affects 3 million Americans. "With just one injection of this gene therapy, the mice remain diabetes-free long term and have a return of normal insulin levels in the body," said Vijay Yechoor, MD, the principal investigator and an assistant professor at...


Word of the Day
virgule
  • A punctuation mark (/) used to separate related items of information.
  • A little rod; a twig.
This word comes from the Late Latin 'virgula,' accentual mark, a diminutive of 'virga,' rod.
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