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Latest Denise Faustman Stories

2009-07-26 19:08:38

Researchers in Cambridge, Mass., found a link between metabolic and immunologic conditions, they said in papers published Sunday in the journal Nature Medicine. They used two over-the-counter allergy medications to reduce both obesity and type 2 diabetes in mice. The papers explained the medications stabilize a population of inflammatory immune cells called mast cells. The researchers also found a white blood cell called a regulatory T cell controls inflammation in fat tissues. Obese people...

2009-07-21 20:20:00

In the new issue of the Developmental Cell journal, a team of scientists at Singapore's Agency for Science, Technology and Research (A*STAR) and the University of North Carolina School of Medicine at Chapel Hill, report research findings about the molecular mechanisms behind the aging process, which has up till now been poorly understood, that offer the possibility that a novel, pharmacological approach could be developed to combat age-related disorders.In their research with lab rodents, the...

2008-12-11 11:30:00

MINNEAPOLIS and ST. PAUL, Minn., Dec. 11 /PRNewswire/ -- The University of Minnesota has received a $40 million pledge for diabetes research from the Richard M. Schulze Family Foundation. Goals for the funding, to be paid over five years, are to capitalize on the University's strength in diabetes research and to accelerate the timeline to translate it into a viable cure for people with type 1 diabetes. The gift is the second largest in the history of the University and the second...

2008-10-30 09:00:11

Bayhill Therapeutics, Inc., a leading developer of therapies for autoimmune diseases, and the Juvenile Diabetes Research Foundation, the world's leading charitable funder of type 1 diabetes research, today announced a partnership to support Bayhill's ongoing Phase I/II human clinical trial of BHT-3021, a DNA vaccine to reverse the immune response that causes type 1 diabetes. BHT-3021 is an antigen-specific immunotherapeutic DNA vaccine designed to reverse the underlying autoimmune...

2008-08-28 12:01:22

U.S. scientists say they confirmed in human experiments a potential type 1 diabetes therapy that might reverse the disease. Researchers led by Dr. Denise Faustman, director of the Massachusetts General Hospital's immunobiology laboratory, confirmed the mechanism behind the potential new therapy. The scientists showed blocking a metabolic pathway regulating the immune system eliminated immune cells that react against a patient's own tissues. Faustman and her team previously discovered a...

2008-08-26 18:00:15

Launching a counter-attack on the immune response that causes insulin-dependent diabetes may provide a revolutionary new way of treating the disease, research has shown. Scientists have found a way to isolate and kill defective immune system cells that wipe out insulin-producing cells in the pancreas. Type 1 diabetes is an autoimmune disease in which the body's "insulin factory" - pancreatic islet cells - is gradually destroyed by specialised white blood cells called "killer" T-cells....

2008-08-26 15:00:17

Scientists at the Stanford University School of Medicine are shedding light on how type-1 diabetes begins. Doctors have known the disease is caused by an autoimmune attack on the pancreas, but the exact trigger of the attack has been unclear. Now, a new study in mice implicates the immune signal interferon-alpha as an early culprit in a chain of events that upend sugar metabolism and make patients dependent on lifelong insulin injections. "We never considered that interferon-alpha...

2008-07-08 09:00:12

EpiVax, Inc, a leader in the field of computational immunology, announced today that it has received a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a division of the National Institutes of Health (NIH), to develop "Epi-13", a novel therapeutic for the prevention and treatment of Type 1 diabetes, a devastating and chronic autoimmune disease that affects three million Americans. NIDDK will provide EpiVax $600,000 over two years to reach...

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2005-01-20 08:19:10

May hold pocket of primitive, embryonic cells, researchers discover HealthDayNews -- The spleen may be a source of potential adult stem cells that contain a protein called Hox11, which is associated with embryonic development and limb regeneration in some animals, says a Massachusetts General Hospital study. It was previously believed that Hox11 was present only during the embryonic development of mammals. "There may be a previously undiscovered pocket of primitive stem cells in the spleen...


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