Latest Diglyceride acyltransferase Stories

Congenital diarrheal disorders (CDD) are a group of rare intestinal diseases that are caused by genetic mutations. In a study published in the Journal of Clinical Investigation, Robert Farese and colleagues at the University of California, San Francisco, identified a family with two of three children affected by CDD. The affected children both carried a rare mutation in the DGAT1 gene. DGAT1 mediates the formation of triglycerides and is being assessed as a therapeutic target in the treatment...

Scientists have discovered that an enzyme associated with the synthesis of fat in the body also promotes healthy skin and hair.The enzyme is called acyl COA: diacylglycerol acyltransferase or DGAT1. Researchers found mice that lack DGAT1 are lean, resistant to diet-induced obesity, are more sensitive to insulin and leptin and have abnormalities in mammary gland development and skin.When researchers deleted the enzyme in mice, they found that a lack of DGAT1 caused levels of retinoic acid (RA)...