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Latest Direct thrombin inhibitor Stories

2012-03-06 10:58:46

Clinicians from the University of Utah report the death of a patient who received a mild brain injury from a ground-level fall while taking the new anticoagulant dabigatran etexilate for non—valve related atrial fibrillation. The authors describe the events that led from a mild traumatic brain injury to the man's death, the largely irreversible dangers of massive hemorrhage from direct thrombin inhibitors such as dabigatran, and the few management options that can be used to counteract...

2010-12-09 19:58:14

Researchers at the University of Cincinnati and Massachusetts General Hospital have found that warfarin, a known anticoagulation (blood-thinning) drug, may not be as beneficial to some patients with atrial fibrillation as previously thought. These findings were published online this week ahead of print in the journal Circulation: Cardiovascular Quality and Outcomes. Warfarin is commonly prescribed to prevent blood clotting, particularly for patients with atrial fibrillation"”a type of...

2010-09-20 17:49:00

RIDGEFIELD, Conn., Sept. 20 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) Cardiovascular and Renal Drugs Advisory Committee today voted 9 to 0 in favor of approving dabigatran etexilate for stroke prevention in patients with atrial fibrillation (AFib). An estimated 2.3 million Americans have AFib(1) and the prevalence is expected to increase 2.5 fold to 5.6 million by 2050,(1) reflecting the growing population of elderly individuals. (1) For 50 years, warfarin has been the...

2010-08-29 07:34:00

RIDGEFIELD, Conn., Aug. 29 /PRNewswire/ -- Boehringer Ingelheim today announced results from a pre-specified, retrospective, un-blinded sub-analysis of the RE-LY® trial - the largest atrial fibrillation outcomes trial ever conducted(2) - were published in The Lancet. The sub-analysis evaluated the primary outcomes of RE-LY® in relation to each center's average time in therapeutic range (cTTR) (INR 2.0-3.0) for patients taking warfarin.(1) Study...

2010-02-26 10:50:00

Study highlights: - A new anti-clotting drug proved as effective as the blood thinner currently used to prevent stroke in atrial fibrillation patients with prior stroke or transient ischemic attacks - The lower dose of the drug dabigatran produced less risk of bleeding in the brain than warfarin did - Dabigatran is not approved in the United States but is available in other countries to prevent blood clots after elective hip and knee replacement surgery SAN ANTONIO, Feb. 26...

2009-09-30 07:37:48

In an article reviewed by F1000 Medicine Faculty Members Robert Ruff, Brian Olshansky and Luis Ruilope, the blood-thinner dabigatran is shown to protect against stroke, blood clotting and major bleeding as effectively as warfarin, but with fewer side effects. The original paper, Dabigatran versus warfarin in patients with atrial fibrillation, by Neal Devaraj and Stuart Connolly et al. in the New England Journal of Medicine, says warfarin (also commonly used in rat poison) has several...

2009-08-30 07:00:00

RIDGEFIELD, Conn., Aug. 30 /PRNewswire/ -- Boehringer Ingelheim today announced that results from the RE-LY(R) (Randomized Evaluation of Long-Term Anticoagulant Therapy, Warfarin, Compared with Dabigatran) study -- the largest atrial fibrillation (AF) outcomes trial ever conducted(1) (18,113 patients in 44 countries worldwide) -- were presented for the first time at the European Society of Cardiology Congress and published online in the New England Journal of Medicine.(2) The primary...

2009-03-20 08:36:00

RIDGEFIELD, Conn., March 20 /PRNewswire/ -- Boehringer Ingelheim today announced that the last patient has completed treatment in the Phase III Randomized Evaluation of Long term Anticoagulant therapy (RE-LY(R)) study. This study compared the long-term efficacy and safety of the oral direct thrombin inhibitor dabigatran etexilate with the current standard therapy, warfarin (target international normalized ratio, INR, 2-3) for the prevention of stroke and non-CNS systemic embolism in patients...


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