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Latest DISC1 Stories

2010-01-05 15:54:52

Mouse study links timing of expression to various abnormalities Scientists have long eyed mutations in a gene known as DISC1 as a possible contributor to schizophrenia and mood disorders, including depression and bipolar disorder. Now, new research led by Johns Hopkins researchers suggests that perturbing this gene during prenatal periods, postnatal periods or both may have different effects in mice, leading to separate types of brain alterations and behaviors with resemblance to...

2009-10-27 09:51:12

Johns Hopkins scientists report having used a commercially available drug to successfully "rescue" animal brain cells that they had intentionally damaged by manipulating a newly discovered gene that links susceptibility genes for schizophrenia and autism. The rescue, described as "surprisingly complete" by the researchers, was accomplished with rapamycin, a drug known to act on a protein called mTOR whose role involves the production of other proteins. The idea to test this drug's...

2009-09-23 13:40:00

Scientists now have a better understanding of a perplexing gene that is associated with susceptibility for a wide spectrum of severely debilitating mental illnesses. Two independent research studies published by Cell Press in the September 24th issue of the journal Neuron provide fascinating insight into the molecular mechanisms that link disrupted-in-schizophrenia 1 (DISC1) with the proper development and migration of neurons in the hippocampus, a brain area involved in learning and memory...

2005-11-16 15:12:16

In new research that helps to reveal the nature of schizophrenia at the cellular level, UCLA scientists report the discovery of unique DNA sequence variations associated with increased risk for schizophrenia, impairments in short- and long-term memory, and other cognitive deficits. "I hope this is the opening salvo in a new molecular approach to fighting schizophrenia," said Tyrone D. Cannon, UCLA's Staglin Family Professor of Psychology, Psychiatry and Human Genetics. "If we're able to...


Word of the Day
omphalos
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.
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