Latest DNA Chip Stories
By Zhao, Qiao Brkljacic, Jelena; Meier, Iris Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope (NE) reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the NE and is associated with the outer surface of the NE in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip NE...
Signature Genomic Laboratories, a company that specializes in microarray-based diagnostic testing of genetic disease in individuals with mental retardation and birth defects, announced it has waived the 25% deposit previously required of patients for insurance billing. Rather than pay a deposit prior to the initiation of testing, patients with private insurance can request an insurance benefits investigation prior to or concurrent with sample processing through Signature's recently...
Researchers at Signature Genomic Laboratories recently published the first large-scale prospective study comparing the detection rate of chromosomal abnormalities--missing or extra pieces of DNA--by microarray analysis in prenatal cases to that of neonatal cases referred with a variety of clinical findings, including congenital anomalies. In the study, the findings of which will appear in the September issue of the journal Prenatal Diagnosis and were electronically published July 22,...
Affymetrix Inc. (Nasdaq:AFFX) announced today that the U.S. Food and Drug Administration (FDA) has granted regulatory clearance to its GCS3000Dx (GCSDx) platform for in vitro gene expression diagnostic testing. The microarray system was granted clearance along with the Pathwork(R) Tissue of Origin (TOO) Test from Pathwork Diagnostics Inc. This test analyzes a tumor's gene expression profile to aid in diagnosing the source of hard-to-identify tumors and is the first of its kind to receive FDA...
Expression Analysis, Inc., the industry's leading provider of genomic services for clinical trails and research, announced today that it has entered into a scientific collaboration with The Immunological Genome Project to provide microarray expression profiling services for this NIH funded project. The project will generate, under rigorous standardized conditions, a complete microarray dissection of gene expression in the immune system of the mouse. The focus is on primary cells ex vivo....
By Ferreira, Fernando J Guo, Cathy; Coleman, John R Carbonic anhydrase (CA; EC 4.2.1.1) catalyzes the interconversion of CO^sub 2^ and HCO^sub 3^^sup -^ and is a major protein constituent of the C^sub 3^ higher plant chloroplast where it is presumed to play a role in photosynthetic carbon assimilation. In this study, we have used both RNA antisense and gene knockout lines to specifically reduce the activity of the chloroplast betaCA1 polypeptide (At3g01500) in the model plant Arabidopsis...
By Rudd, Jason J Keon, John; Hammond-Kosack, Kim E Many race- or isolate-specific disease resistance responses of plants toward pathogens (incompatible interactions) invoke hypersensitive response (HR)-like programmed cell death (PCD) and the coordinated activation of mitogen-activated protein kinases homologous with Arabidopsis (Arabidopsis thaliana) AtMPK6 and AtMPK3 (or tobacco [Nicotiana tabacum] SIPK and WIPK), respectively. Resistance of wheat (Triticum aestivum) leaves to the...
By Pasinetti, Giulio M Hiller-Sturmhofel, Susanne Systems biology approaches may be useful for studying the mechanisms underlying alcohol's harmful effects on the brain. Such approaches already are used in the study of Alzheimer's disease (AD), a progressive neurodegenerative disorder that, with the overall increase in life expectancy, will affect an increasing proportion of the population and become an increasingly serious public health concern. Systems biology approaches such as...
Affymetrix Inc. (Nasdaq:AFFX) today announced that Pathwork Diagnostics Inc. will begin offering a molecular diagnostic test based on the Affymetrix microarray platform. The Pathwork Tissue of Origin Test is one of the first microarray-based diagnostic tests for cancer in the United States. The test is being made available through the recently CLIA-certified Pathwork® Diagnostics Laboratory. There are an estimated 200,000 patients with uncertain primary tumors, including Cancer of...
Some of the worst threats to farm workers and farm animals such as bird flu, foot-and-mouth disease and other emerging viruses could soon be quickly identified by using a simple screening chip developed by scientists from the Institute for Animal Health, scientists will hear today (Monday 31 March 2008) at the Society for General Microbiology's 162nd meeting being held this week at the Edinburgh International Conference Centre."The last major SARS outbreak "“ severe acute respiratory...
