Quantcast

Latest DNA methylation Stories

2011-04-05 15:15:00

IPSWICH, Mass. and SAN DIEGO, April 5, 2011 /PRNewswire/ -- New England Biolabs, Inc. (NEB) and Sequenom, Inc. (NASDAQ: SQNM) jointly announce that they have signed a licensing and co-marketing agreement to commercialize research tools for epigenetics. This agreement is the result of a research collaboration between the two companies that has culminated in the development of the EpiMark(TM) Methylated DNA Enrichment Kit from NEB. (Logo:...

2011-02-09 15:58:00

IPSWICH, Mass., Feb. 9, 2011 /PRNewswire/ -- New England Biolabs (NEB) has published a video protocol with the Journal of Visualized Experiments (JoVE) for the EpiMark(TM) 5-mC and 5-hmC Analysis Kit, one of a suite of new and validated products designed to simplify DNA methylation analysis for epigenetics researchers. The protocol describes a 3-step, PCR-based assay to identify and quantitate 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) within a specific DNA locus....

2011-02-02 20:32:41

Reprogramming adult cells to recapture their youthful "can-do-it-all" attitude appears to leave an indelible mark, found researchers at the Salk Institute for Biological Studies. When the team, led by Joseph Ecker, PhD., a professor in the Genomic Analysis Laboratory, scoured the epigenomes of so-called induced pluripotent stem cells base by base, they found a consistent pattern of reprogramming errors. What's more, these incompletely or inadequately reprogrammed hotspots are maintained when...

2011-02-01 17:27:44

Think of your genome as a dynamic outdoor sculpture. Its shape is, of course, influenced by its structural underpinnings "“ the double helix containing phosphate and two chains of nucleotides attached to a sugar called deoxyribose. These chains wind around each other, linked by hydrogen bonds between the specific bases "“ adenine to thymine and cytosine to guanine. But forces outside your sculpture also act on it. If it were really outside, the forces would be wind, rain, sunlight...

2011-01-24 15:44:16

A new study shows that a test of biomarkers for DNA methylation is technically feasible and could aid in earlier, more precise diagnosis of melanoma. In a paper that appeared online last week in the journal Pigment Cell & Melanoma Research, a team of UNC researchers tested whether DNA methylation profiling could be accomplished on melanoma and mole tissues that had been preserved in fixatives for typical pathology examination after biopsy. They found that results on tissues prepared in...

2011-01-20 16:23:15

Fat appears to associate with some distinctive chemical changes in the DNA "“ a finding that may help explain why obesity can increase the risk for chronic problems such as cardiovascular disease and diabetes, researchers report. The finding, published in BMC Medicine, may one day help identify those at risk and reduce it, according to Dr. Xiaoling Wang, genetic epidemiologist at the Medical College of Georgia's Georgia Prevention Institute. "Losing fat is very difficult; we know that....

2011-01-03 08:24:20

(Ivanhoe Newswire) "“ New insight into the biology of many kinds of less aggressive but lethal brain tumors, or gliomas, opens up a wide variety of possibilities for new therapies, according to this study. The researchers describe how genetic mutation leads to an abnormal metabolic process in the tumors that could be targeted by drug makers."What this tells you is that there are some forms of tumors with a fundamentally altered process," Karl Kelsey, a professor of pathology and...

2010-12-31 12:21:01

(Ivanhoe Newswire) "“ Many mechanisms change the activity of genes. Epigenetics determine when genes are turned on and off, and these epigenetics allow for cells to become cancerous. This was especially seen in ovarian cancer. Researchers at the Duke Cancer Institute have found evidence of epigenetics at work on a genome-wide scale in cases of ovarian cancer. One major biological signaling pathway in particular was found to contain many genes influenced by DNA methylation, a mechanism...

2010-12-23 17:18:28

Study examines effects of supplementation, other factors, on gene methylation People with higher levels of folate in their red blood cells were more likely to have two tumor-suppressing genes shut down by methylation, a chemical off switch for genes, researchers report in the December issue of Cancer Prevention Research. DNA hypermethylation, notes co-author Jean-Pierre Issa, M.D., professor in MD Anderson's Department of Leukemia, is found in a variety of cancers and diseases of aging, such...

2010-12-16 13:18:15

A newly published insight into the biology of many kinds of less-aggressive but still lethal brain tumors, or gliomas, opens up a wide array of possibilities for new therapies, according to scientists at Brown University and the University of California, San Francisco (UCSF). In paper published online Dec. 15 in the Journal of the National Cancer Institute, they describe how a genetic mutation leads to an abnormal metabolic process in the tumors that could be targeted by drug makers. "What...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'kardia,' heart.
Related