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Last updated on April 17, 2014 at 16:26 EDT

Latest DNA methylation Stories

2010-06-02 16:22:23

A previously unknown pattern in DNA methylation - an event that affects cell function by altering gene expression "“ has been uncovered for the first time by stem cell researchers at UCLA, a finding that could have implications in preventing some cancers and correcting defects in human stem cell lines. The team of scientists discovered a relationship between DNA methylation and the positioning of nucleosomes, which compact and regulate access to DNA in the nucleus of a cell. The...

2010-04-18 09:51:21

DNA modification defines early onset glioblastoma, is prevalent in lower grade gliomas HOUSTON - A class of brain tumor that tends to emerge in younger patients but is less aggressive than others can be identified by examining DNA methylation of a specific set of genes, scientists at The University of Texas M. D. Anderson Cancer Center and colleagues with The Cancer Genome Atlas report today online at Cancer Cell. The national research group discovered that hypermethylation is a defining...

2010-04-16 08:26:27

Study identifies patients with longer-than-expected survival times A study conducted by a collaborative team led by researchers from the University of Southern California (USC) may lead to better insight into the clinical outcome for some patients with a particularly aggressive type of brain cancer. The research may also provide a framework for development of targeted drug treatments. The research by The Cancer Genome Atlas (TCGA), published online today in the journal Cancer Cell, used...

2010-04-08 08:51:56

A University of British Columbia doctoral candidate has discovered a previously unknown mechanism for silencing retroviruses, segments of genetic material that can lead to fatal mutations in a cell's DNA. The findings, published April 7 in the journal Nature, could lead to new cancer treatments that kill only tumor cells and leave healthy surrounding tissue unharmed. Danny Leung, a 27-year-old graduate student in the laboratory of Asst. Prof. Matthew Lorincz in the Dept. of Medical Genetics,...

2010-02-25 13:44:55

A paper published online today in Molecular Cell proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a regulator of specific genes. Mutations in MeCP2 cause the autism spectrum disorder Rett Syndrome as well as some cases of neuropsychiatric problems including autism, schizophrenia and learning disabilities. The discovery of MeCP2's global reach was made in the laboratory of Adrian Bird, Ph.D. of the University of Edinburgh. Bird's...

2010-02-23 11:09:24

Scientists from Sydney's Garvan Institute of Medical Research have published a paper, online Feb. 22 in Nature Cell Biology, describing gene expression in a prostate cancer cell: more sweeping, more targeted and more complex than we could ever have imagined, even five years ago. The study shows that changes within the prostate cancer cell 'epigenome' (biochemical processes that target DNA and affect gene expression) alter the expression of many genes, silencing their expression within large...

2010-02-21 11:12:08

News briefing at 2010 AAAS meeting More than three million children have been born as a result of assisted reproductive technologies since the birth of the first "test tube baby" in 1978. While the majority of these children are healthy and normal, as a group they are at greater risk of certain kinds of birth defects and being low birth weight, which is associated with obesity, hypertension and type 2 diabetes later in life. Carmen Sapienza, a geneticist at Temple University School of...

2010-02-16 09:45:00

SPARTA, N.J. and LIEGE, Belgium, Feb. 16 /PRNewswire/ -- Diagenode, an innovative leader providing products and technologies for epigenetics, genomics and diagnostics, and the only provider of complete epigenetics solutions, announced today the launch of its innovative platform for automated epigenetics assays, the SX-8G IP-Star(TM) system ("IP-Star(TM)). The introduction follows the successful completion of six independent collaborations with high-profile research laboratories in the...

2010-02-13 08:29:32

Researchers from the Institute of Psychiatry (IoP), King's College London, have identified numerous novel regions of the genome where the chemical modifications involved in controlling gene expression are influenced by either genetic variation or the parental origin of that particular stretch of DNA. This contradicts previous assumptions that epigenetic signals are generally equal across both copies of a given region of the genome, except at a small number of known imprinted genes. Sequencing...

2010-02-10 08:58:28

Gastric cancer, one of the most common types of cancer, is associated with high mortality rates. In the last decades, a decrease in the worldwide incidence has been observed with some changes in the therapeutic and diagnostic options. However, the prognosis for this disease still remains poor, mainly when the diagnosis is performed at advanced stages. The therapy most effective is still surgical resection and in a significant number of cases, especially in the advanced stage, it is only...