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Latest DNA methylation Stories

2010-01-14 12:37:08

Scientists have found what they believe is the "missing link" between heart failure, our genes and our environment. The study could open up completely new ways of managing and treating heart disease. The Cambridge team compared heart tissue from two groups "“ patients with end-stage heart failure and those with healthy hearts. The diseased tissue came from men who had undergone heart transplants at Papworth Hospital, Cambridge, and the healthy hearts from age-matched victims of road...

2010-01-11 07:55:59

U of Minnesota researcher leads study Researchers at the University of Minnesota have discovered a molecular security system in human cells that deactivates and degrades foreign DNA. This discovery could open the door to major improvements in genetic engineering and gene therapy technologies. Led by Reuben Harris, associate professor of biochemistry, molecular biology and biophysics in the College of Biological Sciences, the report's findings was published online by Nature Structural and...

2010-01-07 18:32:26

Epigenetic diagnosis and therapies, a new strategy for treating cancer In recent years it has been appreciated that there are additional chemical codes in addition to DNA sequence that control the behavior of normal and malignant cells. These additional codes are called "epi"genetic since they are contained outside of the DNA sequence. The investigators have concluded that much of the inter-patient difference in leukemia cell behavior is dependent on a patient's specific epigenetic...

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2010-01-07 08:28:06

The DNA contained within each of our cells is exactly the same, yet different types of cells "“ skin cells, heart cells, brain cells "“ perform very different functions. The ultimate fate of these cells is encoded not just in the DNA, but in a specific pattern of chemical modifications that overlay the DNA structure. These modifications, or epigenetic markers as they are called, are stably carried in our genomes -- except for at times when the cells change their fate, such as what...

2009-11-30 16:30:07

Researchers at Uppsala University and University Children's Hospital in Uppsala have devised powerful new tools for typing cells from children with acute lymphatic leukemia and for prediction of how children with leukemia will respond to chemotherapy. The study was recently published in electronic form by the prestigious hematological journal Blood. Acute leukemia is the most common form of childhood cancer. The new study shows that DNA methylation is a promising tool for predicting disease...

2009-11-05 12:54:04

The same genes that are chemically altered during normal cell differentiation, as well as when normal cells become cancer cells, are also changed in stem cells that scientists derive from adult cells, according to new research from Johns Hopkins and Harvard. Although genetically identical to the mature body cells from which they are derived, induced pluripotent stem cells (iPSCs) are notably special in their ability to self-renew and differentiate into all kinds of cells. And now scientists...

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2009-10-15 06:25:00

Despite the fact that the human genome sequence lists nearly every single DNA base of the roughly 3 billion bases that make up a human genome, it has remained a biological mystery as to how its function is regulated. Now, scientists from the Salk Institute have revealed the first detailed map of the human epigenome, which is the network of chemical switches that regulates activation of human genes. The human genome was decoded almost 10 years ago, which plainly showed the building blocks of...

2009-10-12 07:00:00

ST. LOUIS, Oct. 12 /PRNewswire/ -- Orion Genomics today announced that it has entered into a multi-year collaboration and license agreement with the molecular diagnostics unit of Novartis Pharma AG. Under the collaboration, the parties seek to discover novel epigenetic biomarkers, and both parties have rights to independently develop and commercialize diagnostic products in their respective fields. Under the terms of the agreement, Orion Genomics also grants Novartis non-exclusive...

2009-10-08 09:44:16

Researchers at Henry Ford Hospital have identified tumor-suppressing genes that may provide a more accurate diagnosis of disease stage and survival for laryngeal cancer patients than current standards. The study finds genetic abnormalities of the ESR1(estrogen specific receptor 1) gene and the HIC1 (hypermethylated in cancer 1) gene are predictors of late-stage laryngeal cancer and shorter survival, respectively, for patients with the disease. Study results was presented Wednesday, Oct. 7 at...

2009-10-06 13:36:19

During cell division, whether hematopoietic stem cells (HSCs) will develop into new stem cells (self-renewal) or differentiate into other blood cells depends on a chemical process called DNA methylation. These were the findings of researchers at the laboratory of Dr. Frank Rosenbauer of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch in cooperation with the laboratory of Professor Sten Eirik W. Jacobsen (Lund University, Sweden and the University of Oxford, England)....


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.