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Latest DNA methylation Stories

2009-09-21 09:54:40

Scientists have identified how a protein enables sections of so-called junk DNA to be cut and pasted within genetic code "“ a finding which could speed development of gene therapies. The study by researchers at the University of Edinburgh sheds light on the process, known as DNA transposition, in which shifted genes have a significant effect on the behavior of neighboring genes. In the human genome, rearrangement of antibody genes can enable the immune system to target infection more...

2009-09-02 07:53:22

Genes that regulate the energy consumption of cells have a different structure and expression in type II diabetics than they do in healthy people, according to a new study from the Swedish medical university Karolinska Institute published in Cell Metabolism. The researchers believe that these "Ëœepigenetic mutations' might have a key part to play in the development of the disease.Type II diabetes is characterized by a lower sensitivity to insulin in muscles and organs, and a reduced...

2009-08-22 11:54:06

A preliminary evaluation of methylation of two gene promoters in fecal DNA showed promise as a noninvasive method to detect colorectal and gastric cancers, according to a new study published online August 21 in the Journal of the National Cancer Institute. Because many patients are reluctant to undergo invasive tests for the detection of gastrointestinal cancers, the development of nonintrusive screening tests is desirable. Especially in cancer patients, some cells are sloughed off from the...

2009-08-16 13:07:39

A study published in this week's online issue of Nature Biotechnology, demonstrates a unique and highly sensitive method for detecting methylation-associated cancers. Chemical modification of DNA via the addition or deletion of methyl groups has been established as a common biological means of activating or silencing genes. Abnormal levels of DNA methylation, which effectively disrupt the genes responsible for normal cell cycle regulation, has been implicated in a number of different cancers,...

2009-08-04 13:25:00

In many types of cancer, parts of the genetic material of tumor cells are switched off by chemical labels called methyl groups. This kind of methyl labeling ranges among the epigenetic changes that do not change the sequence of DNA building blocks. Such labels are found particularly often in genes which act as important inhibitors of pathogenic cell growth.Cancer researchers do not know why healthy cells and cancer cells differ in their methylation patterns and why it is particularly the...

2009-07-30 10:17:38

UCD Conway researchers have characterized epigenetic signature changes in prostate cells under conditions of low oxygen levels that may lead to tumor development. The results of the study published this month in the scientific journal, Human Molecular Genetics may provide important targets for the early detection and manipulation of prostate cancer.Chronic hypoxia, or low tissue oxygen levels, is a natural feature of the aging prostate either due to declining blood flow to the area or local...

2009-07-28 09:53:00

Distinctive patterns of genes turned off "“ or left on "“ in healthy versus cancerous cells could enable early screening for many common cancers and maybe help avoid them, Medical College of Georgia scientists say.Researchers are comparing chemical alterations, called DNA methylation, in the body's basic building block in healthy colon, breast, brain and lymphatic cells and their cancerous counterpart to find telltale patterns that could one day be detected in the blood, urine or...

2009-06-29 08:50:00

Swedish researchers have discovered that babies born by Caesarean section experience changes to the DNA pool in their white blood cells, which could be connected to altered stress levels during this method of delivery, according to the July issue of Acta Paediatrica.  It is thought that these genetic changes, which differ from normal vaginal deliveries, could explain why people delivered by C-section are more susceptible to immunological diseases such as diabetes and asthma in later...

2009-06-26 08:05:00

Discovery may offer potential strategy for therapies to clear HIVScientists at the Gladstone Institutes of Virology and Immunology (GIVI) have found another clue that may lead to eradication of HIV from infected patients who have been on antiretroviral therapy. A real cure for HIV has been elusive because the virus can "hide" in a latent form in resting CD4-T cells. By understanding this "latency" effect, researchers can identify ways to reactivate the virus and enable complete clearance by...

2009-05-18 18:54:30

Inhalation of some particulates can cause some genes to become reprogrammed, affecting the development and outcome of cancers, Italian researchers said. Dr. Andrea Baccarelli of the University of Milan enrolled 63 healthy subjects who worked in a foundry near Milan. Blood DNA samples were collected on the morning of the first day of the work week, and again after three days of work. Comparing these samples revealed that significant changes had occurred in four genes associated with tumor...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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