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Last updated on April 24, 2014 at 16:36 EDT

Latest DNA methylation Stories

2009-02-24 07:42:27

Current research suggests that a new technique to determine tumor methylation status can be used in archived tissue samples. The related report by Balic et al, "High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis," appears in the March 2009 issue of The Journal of Molecular Diagnostics.DNA in tumors is often altered compared with DNA in normal tissues. One common DNA alteration in cancerous tissue...

2009-02-10 10:07:15

An estimated 15% of cancer cases can be linked to a viral infection, however the biological changes that cause some asymptomatic carriers of a virus to develop full-blown tumors are not well understood. In a study published online in Genome Research, scientists have mapped a chemical modification of DNA in three oncogenic viruses (Epstein-Barr, human papilloma virus, and hepatitis B virus) and found that the viral genome undergoes critical changes during the progression of disease, with...

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2009-01-18 14:51:16

Scientists who study how human chemistry can permanently turn off genes have typically focused on small islands of DNA believed to contain most of the chemical alterations involved in those switches. But after an epic tour of so-called DNA methylation sites across the human genome in normal and cancer cells, Johns Hopkins scientists have found that the vast majority of the sites aren't grouped in those islands at all, but on nearby regions that they've named "shores." "Our study suggests that...

2009-01-12 06:00:00

ANN ARBOR, Mich., Jan. 12 /PRNewswire/ -- Rubicon Genomics today announced a licensing agreement with Abbott, which marks the achievement of significant milestones within their on-going Research and Option Agreement for development and commercialization of Rubicon MethylPlex(TM) methylation detection technology for the diagnosis and prognosis of cancer. Under the terms of the agreement Abbott receives a non-exclusive license to MethylPlex for in vitro molecular diagnostics to detect the...

2008-12-15 09:59:31

Eric Selker's lab reports progress on biochemical communications among proteins involved in gene silencingResearchers in a University of Oregon lab have shed more light on the mechanism that regulates DNA methylation, a fundamental biological process in which a methyl group is attached to DNA, the genetic material in cells of living organisms.DNA methylation is essential for normal growth and development in plants and animals. It has been implicated in long-term memory, and irregularities in...

2008-12-04 17:00:31

Gene packaging tells story of cancer developingTo decipher how cancer develops, Johns Hopkins Kimmel Cancer Center investigators say researchers must take a closer look at the packaging.Specifically, their findings in the December 2, 2008, issue of PLoS Biology point to the three dimensional chromatin packaging around genes formed by tight, rosette-like loops of Polycomb group proteins (PcG). The chromatin packaging, a complex combination of DNA and proteins that compress DNA to fit inside...

2008-11-18 09:31:44

Although it's the deadliest cancer, not all smokers are affected by lung cancer equally. Now, doctors are one step closer to understanding why some patients develop lung cancer while others do not. "More than 50 percent of newly diagnosed lung cancer patients are former smokers," Emily A. Vucic, a graduate student at the British Columbia Cancer Research Centre in Vancouver, B.C., and member of the research team, was quoted as saying. "Understanding why some former smokers develop lung cancer...

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2008-11-17 15:10:00

Canadian researchers are trying to answer why some smokers develop lung cancer while others remain disease free, despite similar lifestyle changes. Results were presented at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research. According to the Centers for Disease Control and Prevention, more people die from lung cancer than any other cancer type. In fact, according to 2004 data, more people died from lung cancer...

2008-10-31 18:00:39

U.S. and Dutch researchers suggest prenatal exposure to famine can lead to epigenetic -- gene -- changes that may affect a person's health into midlife. Researchers at Columbia University Mailman School of Public Health in New York and the Leiden University Medical Center in the Netherlands said previous studies have suggested that adult disease risk may be associated with adverse environmental conditions early in development, these data are the first to show that early-life environmental...

2008-10-30 03:00:23

ST. LOUIS, Oct. 30 /PRNewswire-FirstCall/ -- Sigma-Aldrich today introduced its Imprint(TM) Methylated DNA Quantification Kit (MDQ1) for epigenetic research http://www.sigma-aldrich.com/mdq1. The Methylated DNA Quantification Kit employs a familiar ELISA-like procedure, with no radioactivity or chromatography, to measure global methylation in less than four hours. The kits are effective with a DNA input as low as 5ng of fully methylated DNA and are arranged in a flexible 8-well assay...