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Latest DNA methylation Stories

2009-07-30 10:17:38

UCD Conway researchers have characterized epigenetic signature changes in prostate cells under conditions of low oxygen levels that may lead to tumor development. The results of the study published this month in the scientific journal, Human Molecular Genetics may provide important targets for the early detection and manipulation of prostate cancer.Chronic hypoxia, or low tissue oxygen levels, is a natural feature of the aging prostate either due to declining blood flow to the area or local...

2009-07-28 09:53:00

Distinctive patterns of genes turned off "“ or left on "“ in healthy versus cancerous cells could enable early screening for many common cancers and maybe help avoid them, Medical College of Georgia scientists say.Researchers are comparing chemical alterations, called DNA methylation, in the body's basic building block in healthy colon, breast, brain and lymphatic cells and their cancerous counterpart to find telltale patterns that could one day be detected in the blood, urine or...

2009-06-29 08:50:00

Swedish researchers have discovered that babies born by Caesarean section experience changes to the DNA pool in their white blood cells, which could be connected to altered stress levels during this method of delivery, according to the July issue of Acta Paediatrica.  It is thought that these genetic changes, which differ from normal vaginal deliveries, could explain why people delivered by C-section are more susceptible to immunological diseases such as diabetes and asthma in later...

2009-06-26 08:05:00

Discovery may offer potential strategy for therapies to clear HIVScientists at the Gladstone Institutes of Virology and Immunology (GIVI) have found another clue that may lead to eradication of HIV from infected patients who have been on antiretroviral therapy. A real cure for HIV has been elusive because the virus can "hide" in a latent form in resting CD4-T cells. By understanding this "latency" effect, researchers can identify ways to reactivate the virus and enable complete clearance by...

2009-05-18 18:54:30

Inhalation of some particulates can cause some genes to become reprogrammed, affecting the development and outcome of cancers, Italian researchers said. Dr. Andrea Baccarelli of the University of Milan enrolled 63 healthy subjects who worked in a foundry near Milan. Blood DNA samples were collected on the morning of the first day of the work week, and again after three days of work. Comparing these samples revealed that significant changes had occurred in four genes associated with tumor...

2009-05-18 09:21:56

A Chinese scientist group working in College of Life Science, Zhejiang University, has shown that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island has a parental differentially methylated region (DMR). These results indicate that the evolutionary foundation of genomic imprinting exists in lower vertebrates and genomic imprinting should not be considered as a unique evolutionary event of mammals. The study is reported in volume 54 (Issue 8, April, 2009) of Chinese Science...

2009-05-18 07:59:46

Exposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases.The research will be presented on Sunday, May 17, at the 105th International Conference of the American Thoracic Society in San Diego."Recently, changes in gene programming due to a...

2009-04-17 11:19:55

The discovery of a new nucleotide in the mouse brain opens the door to a new domain of epigenetic DNA modificationAnyone who studied a little genetics in high school has heard of adenine, thymine, guanine and cytosine "“ the A,T,G and C that make up the DNA code. But those are not the whole story. The rise of epigenetics in the past decade has drawn attention to a fifth nucleotide, 5-methylcytosine (5-mC), that sometimes replaces cytosine in the famous DNA double helix to regulate which...

2009-02-24 07:42:27

Current research suggests that a new technique to determine tumor methylation status can be used in archived tissue samples. The related report by Balic et al, "High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis," appears in the March 2009 issue of The Journal of Molecular Diagnostics.DNA in tumors is often altered compared with DNA in normal tissues. One common DNA alteration in cancerous tissue...

2009-02-10 10:07:15

An estimated 15% of cancer cases can be linked to a viral infection, however the biological changes that cause some asymptomatic carriers of a virus to develop full-blown tumors are not well understood. In a study published online in Genome Research, scientists have mapped a chemical modification of DNA in three oncogenic viruses (Epstein-Barr, human papilloma virus, and hepatitis B virus) and found that the viral genome undergoes critical changes during the progression of disease, with...


Word of the Day
tessitura
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.