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Latest DNA methylation Stories

2009-05-18 09:21:56

A Chinese scientist group working in College of Life Science, Zhejiang University, has shown that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island has a parental differentially methylated region (DMR). These results indicate that the evolutionary foundation of genomic imprinting exists in lower vertebrates and genomic imprinting should not be considered as a unique evolutionary event of mammals. The study is reported in volume 54 (Issue 8, April, 2009) of Chinese Science...

2009-05-18 07:59:46

Exposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases.The research will be presented on Sunday, May 17, at the 105th International Conference of the American Thoracic Society in San Diego."Recently, changes in gene programming due to a...

2009-04-17 11:19:55

The discovery of a new nucleotide in the mouse brain opens the door to a new domain of epigenetic DNA modificationAnyone who studied a little genetics in high school has heard of adenine, thymine, guanine and cytosine "“ the A,T,G and C that make up the DNA code. But those are not the whole story. The rise of epigenetics in the past decade has drawn attention to a fifth nucleotide, 5-methylcytosine (5-mC), that sometimes replaces cytosine in the famous DNA double helix to regulate which...

2009-02-24 07:42:27

Current research suggests that a new technique to determine tumor methylation status can be used in archived tissue samples. The related report by Balic et al, "High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis," appears in the March 2009 issue of The Journal of Molecular Diagnostics.DNA in tumors is often altered compared with DNA in normal tissues. One common DNA alteration in cancerous tissue...

2009-02-10 10:07:15

An estimated 15% of cancer cases can be linked to a viral infection, however the biological changes that cause some asymptomatic carriers of a virus to develop full-blown tumors are not well understood. In a study published online in Genome Research, scientists have mapped a chemical modification of DNA in three oncogenic viruses (Epstein-Barr, human papilloma virus, and hepatitis B virus) and found that the viral genome undergoes critical changes during the progression of disease, with...

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2009-01-18 14:51:16

Scientists who study how human chemistry can permanently turn off genes have typically focused on small islands of DNA believed to contain most of the chemical alterations involved in those switches. But after an epic tour of so-called DNA methylation sites across the human genome in normal and cancer cells, Johns Hopkins scientists have found that the vast majority of the sites aren't grouped in those islands at all, but on nearby regions that they've named "shores." "Our study suggests that...

2009-01-12 06:00:00

ANN ARBOR, Mich., Jan. 12 /PRNewswire/ -- Rubicon Genomics today announced a licensing agreement with Abbott, which marks the achievement of significant milestones within their on-going Research and Option Agreement for development and commercialization of Rubicon MethylPlex(TM) methylation detection technology for the diagnosis and prognosis of cancer. Under the terms of the agreement Abbott receives a non-exclusive license to MethylPlex for in vitro molecular diagnostics to detect the...

2008-12-15 09:59:31

Eric Selker's lab reports progress on biochemical communications among proteins involved in gene silencingResearchers in a University of Oregon lab have shed more light on the mechanism that regulates DNA methylation, a fundamental biological process in which a methyl group is attached to DNA, the genetic material in cells of living organisms.DNA methylation is essential for normal growth and development in plants and animals. It has been implicated in long-term memory, and irregularities in...

2008-12-04 17:00:31

Gene packaging tells story of cancer developingTo decipher how cancer develops, Johns Hopkins Kimmel Cancer Center investigators say researchers must take a closer look at the packaging.Specifically, their findings in the December 2, 2008, issue of PLoS Biology point to the three dimensional chromatin packaging around genes formed by tight, rosette-like loops of Polycomb group proteins (PcG). The chromatin packaging, a complex combination of DNA and proteins that compress DNA to fit inside...

2008-11-18 09:31:44

Although it's the deadliest cancer, not all smokers are affected by lung cancer equally. Now, doctors are one step closer to understanding why some patients develop lung cancer while others do not. "More than 50 percent of newly diagnosed lung cancer patients are former smokers," Emily A. Vucic, a graduate student at the British Columbia Cancer Research Centre in Vancouver, B.C., and member of the research team, was quoted as saying. "Understanding why some former smokers develop lung cancer...


Word of the Day
tesla
  • The unit of magnetic flux density in the International System of Units, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
This word is named for Nikola Tesla, the inventor, engineer, and futurist.