Latest DNA methylation Stories
April Flowers for redOrbit.com - Your Universe Online If you look around at your friends and family, it is clear our biological clocks tick differently. Women tend to live longer than men do, some individuals can look years younger – or older – than their chronological age, and diseases can affect our aging process. The University of California, San Diego School of Medicine led a new study, published online in the journal Molecular Cell, that describes markers and a model that...
ANN ARBOR, Mich., Nov. 1, 2012 /PRNewswire/ -- Rubicon Genomics, Inc. today announced that it has partnered with Diagenode SA to integrate Rubicon's ThruPLEX(TM) technology into Diagenode's epigenetics platforms to increase the efficiency and quality of DNA sample preparation for chromatin immunoprecipitation (ChIP) applications. The new agreement allows Diagenode to incorporate the Rubicon ThruPLEX-FD technology into its new MicroPLEX Library Preparation Kit for ChIP-seq studies...
A University of British Columbia and Centre for Molecular Medicine and Therapeutics (CMMT) study has revealed that childhood poverty, stress as an adult, and demographics such as age, sex and ethnicity, all leave an imprint on a person’s genes. And, that this imprint could play a role in our immune response. The study was published last week in a special volume of the Proceedings of the National Academy of Sciences that looks at how experiences beginning before birth and in the years...
It can be detected an epigenetic alteration associated with an increased risk of breast cancer in the sick twin a few years before the clinical diagnosis Monozygotic twins have the same genome, that is, the same DNA molecule in both siblings. Despite being genetically identical, both twins may have different diseases at different times. This phenomenon is called "twin discordance". But how can people who have the same genetic sequence present different pathologies and at different ages?...
Over the last two decades, scientists have come to understand that the genetic code held within DNA represents only part of the blueprint of life. The rest comes from specific patterns of chemical tags that overlay the DNA structure, determining how tightly the DNA is packaged and how accessible certain genes are to be switched on or off. As researchers have uncovered more and more of these "epigenetic" tags, they have begun to wonder how they are all connected. Now, research from the...
redOrbit Staff & Wire Reports - Your Universe Online Genetic analysis of different types of worker bees has for the first time demonstrated a link between reversible chemical tags on an organism's DNA and their behavioral patterns. Andy Feinberg, a professor of molecular medicine and the director of the Center for Epigenetics at Hopkins' Institute for Basic Biomedical Sciences, and colleagues used a method they called CHARM (comprehensive high-throughput arrays for relative...
ST. LOUIS, Sept. 14, 2012 /PRNewswire/ -- The sequencing of the human genome was once hailed by scientists to be the harbinger of medical miracles. Yet, deciphering our DNA brought us no closer to understanding -- much less finding effective preventive approaches for -- major chronic diseases. But new groundbreaking research is uncovering a higher level of complexity beyond genetic variation. Even better news: proper nutrition can produce positive changes at this higher level. A...
April Flowers for redOrbit.com - Your Universe Online Much has been made of the fact that ninety-six percent of a chimpanzee's genome is the same as a human's. However, it is that other four percent, and the vast differences, that pique the interest of Georgia Tech's Soojin Yi. For example, why do humans have a high risk of cancer while chimps rarely develop the disease? In a new study published in September's American Journal of Human Genetics, Yi looked at brain samples from each...
Thomas Jefferson University team shifts a longstanding paradigm for epigenetic markers It's widely accepted that molecular mechanisms mediating epigenetics include DNA methylation and histone modifications, but a team from Thomas Jefferson University has evidence to the contrary regarding the role of histone modifications. A study of Drosophila embryos from Jefferson's Department of Biochemistry and Molecular Biology published ahead of print in Cell August 23 found that parental...
Chimpanzees rarely get cancer, or a variety of other diseases that commonly arise in humans, but their genomic DNA sequence is nearly identical to ours. So, what's their secret? Researchers reporting in the September issue of the American Journal of Human Genetics, a Cell Press journal, have found that differences in certain DNA modifications, called methylation, might play a role. The researchers discovered hundreds of genes that display different patterns of methylation between the two...
