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Last updated on April 20, 2014 at 8:28 EDT

Latest DNA methylation Stories

2012-08-24 00:35:59

Thomas Jefferson University team shifts a longstanding paradigm for epigenetic markers It's widely accepted that molecular mechanisms mediating epigenetics include DNA methylation and histone modifications, but a team from Thomas Jefferson University has evidence to the contrary regarding the role of histone modifications. A study of Drosophila embryos from Jefferson's Department of Biochemistry and Molecular Biology published ahead of print in Cell August 23 found that parental...

2012-08-24 00:32:17

Chimpanzees rarely get cancer, or a variety of other diseases that commonly arise in humans, but their genomic DNA sequence is nearly identical to ours. So, what's their secret? Researchers reporting in the September issue of the American Journal of Human Genetics, a Cell Press journal, have found that differences in certain DNA modifications, called methylation, might play a role. The researchers discovered hundreds of genes that display different patterns of methylation between the two...

New Purpose Found For Archived Guthrie Cards
2012-08-23 07:06:49

Over the last 50 years, the spotting of newborn's blood onto filter paper for disease screening, called Guthrie cards, has become so routine that since 2000, more than 90% of newborns in the United States have had Guthrie cards created. In a study published online in Genome Research, researchers have shown that epigenetic information stored on archived Guthrie cards provides a retrospective view of the epigenome at birth, a powerful new application for the card that could help understand...

Seeds Of Defense Being Planted
2012-08-08 07:16:52

Salk study finds stress triggers widespread epigenetic changes that aid in disease resistance It was long thought that methylation, a crucial part of normal organism development, was a static modification of DNA that could not be altered by environmental conditions. New findings by researchers at the Salk Institute for Biological Studies, however, suggest that the DNA of organisms exposed to stress undergo changes in DNA methylation patterns that alter how genes are regulated. The...

2012-07-16 10:21:04

Your genes determine much about you, but environment can have a strong influence on your genes even before birth, with consequences that can last a lifetime. In a study published online in Genome Research, researchers have for the first time shown that the environment experienced in the womb defines the newborn epigenetic profile, the chemical modifications to DNA we are born with, that could have implications for disease risk later in life. Epigenetic tagging of genes by a chemical...

2012-07-06 11:45:15

New research in the FASEB Journal suggests that DNA methylation is responsible for switching on and off a gene that produces the MMP13 enzyme that is known to be important in the destruction of cartilage In what could be a breakthrough in the practical application of epigenetic science, U.K. scientists used human tissue samples to discover that those with osteoarthritis have a signature epigenetic change (DNA methylation) responsible for switching on and off a gene that produces a...

Epigenetics Changes Genes In Rheumatoid Arthritis
2012-07-03 12:19:12

It's not just our DNA that makes us susceptible to disease and influences its impact and outcome. Scientists are beginning to realize more and more that important changes in genes that are unrelated to changes in the DNA sequence itself — a field of study known as epigenetics — are equally influential. A research team at the University of California, San Diego — led by Gary S. Firestein, professor in the Division of Rheumatology, Allergy and Immunology at UC San Diego...

2012-06-16 01:07:59

Previously unknown repair byproduct could be ℠master regulator´ of many basic cell processes University of Texas Medical Branch at Galveston researchers have found a surprising connection between a key DNA-repair process and a cellular signaling network linked to aging, heart disease, cancer and other chronic conditions. The discovery promises to open up an important new area of research – one that could ultimately yield novel treatments for a wide variety of diseases....

2012-05-22 21:26:36

The latest study was published as a highlighted paper in Nature Communications In a highlighted paper published online in Nature Communications, researchers from Sichuan Agricultural University and BGI, the world's largest genomics organization, reported the atlas of DNA methylomes in porcine adipose and muscle tissues, providing a valuable epigenomic source for obesity prediction and prevention as well as boosting the further development of pig as a model animal for human obesity...

2012-05-14 22:22:55

Alterations to the "on-off" switches of genes occur early in the development of prostate cancer and could be used as biomarkers to detect the disease months or even years earlier than current approaches, a Mayo Clinic study has found. These biomarkers – known as DNA methylation profiles – also can predict if the cancer is going to recur and if that recurrence will remain localized to the prostate or, instead, spread to other organs. The study, published in the journal Clinical...