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Latest DNA mismatch repair Stories

Detailed Look At A DNA Repair Protein In Action
2013-10-24 07:07:42

Lawrence Berkeley National Laboratory Provides New Insight into Genome Integrity and Biological Detection of Mismatched DNA Errors in the human genetic code that arise from mismatched nucleotide base pairs in the DNA double helix can lead to cancer and other disorders. In microbes, such errors provide the basis for adaption to environmental stress. As one of the first responders to these genetic errors, a small protein called MutS – for “Mutator S” – controls the integrity of...

2013-08-19 10:33:22

Researchers at Michigan State University use TACC supercomputers to understand DNA bending and repair mechanisms The biological information that makes us unique is encoded in our DNA. DNA damage is a natural biological occurrence that happens every time cells divide and multiply. External factors such as overexposure to sunlight can also damage DNA. Understanding how the human body recognizes damaged DNA and initiates repair fascinates Michael Feig, professor of biochemistry and...

2011-06-06 13:54:51

Among various genetic mutations for individuals with Lynch syndrome, a hereditary cancer syndrome that carries a high risk of colon cancer and an above-normal risk of other cancers, researchers have identified mutations associated with a lower cancer risk and mutations associated with an increased risk for ovarian and endometrial cancer, according to a study in the June 8 issue of JAMA, a theme issue on cancer. The study is being published early online to coincide with the American Society of...

2011-05-23 07:23:05

(Ivanhoe Newswire) -- A new study shows a person's DNA repair system may play a role in determining if their cancer will recur. Investigators found colorectal cancer patients with defects in mismatched repair -- one of the body's systems for repairing DNA damage -- have lower rates of recurrence and better survival rates. About 15 percent of colorectal cancers are associated with mismatch repair defects. Researchers say it has never been clear whether these mismatches are linked to cancer...

2011-05-20 12:58:30

Colorectal cancer patients with defects in mismatch repair--one of the body's systems for repairing DNA damage--have lower recurrence rates and better survival rates than patients without such defects, according to a study published online May 19th in the Journal of the National Cancer Institute. About 15% of colorectal cancers are associated with mismatch repair defects. Some defects are caused by the inherited gene mutations found in Lynch syndrome and others occur by chance, or...

2010-04-30 12:19:18

New research shows for the first time that molecules called microRNA can silence genes that protect the genome from cancer-causing mutations. The study, led by researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, shows that microRNA-155 (miR-155) can inhibit the activity of genes that normally correct the damage when the wrong bases are paired in DNA. The loss or silencing of these genes, which are...

2005-10-03 15:03:03

ROCHESTER, Minn. -- Mayo Clinic researchers have discovered the inner workings of a defective DNA repair process and are first to explain why certain mutations are not corrected in cells. The finding is important because genetic instability and accumulations of mutations lead to disease. This discovery may lead to ways of fixing the process to avoid Huntington's disease and some types of colon cancer. The Mayo team discovered that under certain conditions, a key protein fails to recognize a...


Word of the Day
omphalos
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.
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