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Latest DNA polymerase Stories

2011-04-16 00:41:30

A Berkeley Lab-led team deciphers the structure of FEN1, a key player in DNA replication and repair DNA replication is critical to the life of all organisms, insuring that each new cell, as well as each new offspring, gets an accurate copy of the genome. Among the legions of proteins that do the work so essential to a cell's survival, the DNA-slicing "flap endonuclease" FEN1 plays a key role. The structure of human FEN1 has now been solved by an international team of scientists led by the...

2011-02-14 15:13:00

IPSWICH, Mass., Feb. 14, 2011 /PRNewswire/ -- New England Biolabs has expanded its line of PCR reagents to include OneTaq(TM) and OneTaq Hot Start DNA Polymerases. Optimized blends of Taq and Deep Vent(®) DNA Polymerases, these new products offer robust amplification across a wide range of templates, including routine, AT-rich and GC-rich amplicons. The 3´-5´ exonuclease activity of Deep Vent increases the fidelity and robustness of...

2011-01-18 22:07:10

UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads to cancer and other diseases. The enzyme, known as Rad18, detects a protein called DNA polymerase eta (Pol eta) and accompanies it to the sites of sunlight-induced DNA damage, enabling accurate repair. When Pol eta is not present, alternative error-prone polymerases take...

2010-11-09 11:27:50

Shutting down enzyme that controls DNA repair could boost effects of traditional chemo drugs Suppressing cancer cells' ability to replicate damaged DNA could dramatically enhance the effectiveness of chemotherapy drugs such as cisplatin, according to a new pair of papers from MIT biologists. In studies of mice, the researchers found that slowing down a specific system for tolerating DNA damage not only prolonged survival but also prevented relapsed tumors from becoming resistant to...

2009-12-03 14:00:00

Research could lead to an understanding of how accurate DNA replication occurs to prevent mutations known to result in cancer and genetic diseases DETROIT, Dec. 3 /PRNewswire-USNewswire/ -- Wayne State researchers have for the first time observed the movement of a single molecule of DNA polymerase as it incorporates nucleotides one by one. More significantly, they have identified a previously unknown step that they speculate is part of the proofreading process known to prevent the...

2009-05-04 10:16:28

One can have a dream, two can make that dream so real, goes a popular song. Now a Weizmann Institute study has revealed that it takes two to perform an essential form of DNA repair. Prof. Zvi Livneh of the Weizmann Institute's Biological Chemistry Department has been studying DNA repair for some two decades: "ËœConsidering that the DNA of each cell is damaged about 20,000 times a day by radiation, pollutants and harmful chemicals produced within the body, it's obvious that without...

2009-01-07 09:05:00

It's a little like finding out that Superman is actually Clark Kent.A team of biologists at Washington University in St. Louis has discovered that two vital cellular components, nuclear RNA Polymerases IV and V (Pol IV and V), found only in plants, are actually specialized forms of RNA Polymerase II, an essential enzyme of all eukaryotic organisms, including humans."We've caught evolution in the act," said Craig Pikaard, Ph.D., WUSTL professor of biology in Arts & Sciences. "We've known...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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