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Latest DNA repair Stories

2011-01-18 22:07:10

UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads to cancer and other diseases. The enzyme, known as Rad18, detects a protein called DNA polymerase eta (Pol eta) and accompanies it to the sites of sunlight-induced DNA damage, enabling accurate repair. When Pol eta is not present, alternative error-prone polymerases take...

2011-01-06 16:34:18

Chromosome crisis common in cancer causation Remarkable new research overthrows the conventional view that cancer always develops in a steady, stepwise progression. It shows that in some cancers, the genome can be shattered into hundreds of fragments in a single cellular catastrophe, wreaking mutation on a massive scale. The scars of this chromosomal crisis are seen in cases from across all the common cancer types, accounting for at least one in forty of all cancers. The phenomenon is...

2011-01-06 16:28:01

Most of the time cancer seems to creep up gradually over time; cells become premalignant, then increasingly abnormal before they become cancerous. But sometimes cancers seem to pop up as if out of nowhere. Now, researchers reporting in the January 7th issue of the journal Cell, a Cell Press publication, have new evidence to explain how that can happen. Based on the DNA sequences of multiple cancer samples of various types, they show that cancer can arise suddenly in the aftermath of one-off...

2010-12-11 00:32:30

Scientists have discovered how a network of repair proteins enables bacteria to prioritise the repair of the most heavily used regions of the DNA molecules that carry the instructions necessary for living cells to function. The research, carried out by academics at the University of Bristol and published in Molecular Cell (Dec. 2010), reveals that there are greater similarities between the DNA repair systems of bacteria and humans than had been suspected. When the chemical "letters" in a...

2010-12-08 02:00:35

The sun's ultraviolet light activates an enzyme that helps skin cancer cells survive and proliferate, researchers report. The finding shows another way cancer pirates normal body functions as it points toward better treatment for the million new cases of non-melanoma skin cancers diagnosed in the United States annually, said Dr. Wendy Bollag, corresponding author of the study in Oncogene. Bollag is a cell physiologist at the Medical College of Georgia and the Charlie Norwood Veterans Affairs...

2010-11-29 18:40:22

Breast cancers that arise sporadically, rather than through inheritance of certain genes, likely start with defects of DNA repair mechanisms that allow environmentally triggered mutations to accumulate, according to researchers at the University of Pittsburgh School of Medicine, Magee-Womens Hospital of UPMC and the University of Pittsburgh Cancer Institute. The findings, reported this week in the early online edition of the Proceedings of the National Academy of Sciences, indicate that...

2010-11-18 13:09:57

A new drug that targets proteins responsible for helping cancer cells to repair damage to their DNA has shown promising anti-tumour activity in its first trial in humans. Some patients with a range of solid tumours, many of whom had been treated unsuccessfully for their cancer with other therapies, have seen their tumours shrink or stabilise for periods of between 46 days to more than a year. The research will be presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and...

2010-11-12 06:30:00

OMAHA, Neb., Nov. 12, 2010 /PRNewswire/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO) today announced that it has been awarded a research and development grant totaling $1,070,453.32 from the U.S. government under HR: 3590 - Patient Protection and Affordable Care Act (the "Act") in immediately available funds. This is among the largest awards for any one company under the Act. Four of the Company's R&D programs received the highest maximum allowable award of $244,479.25 each,...

2010-11-09 11:27:50

Shutting down enzyme that controls DNA repair could boost effects of traditional chemo drugs Suppressing cancer cells' ability to replicate damaged DNA could dramatically enhance the effectiveness of chemotherapy drugs such as cisplatin, according to a new pair of papers from MIT biologists. In studies of mice, the researchers found that slowing down a specific system for tolerating DNA damage not only prolonged survival but also prevented relapsed tumors from becoming resistant to...

2010-11-04 17:52:30

The findings could help scientists devise optimal therapies for the devastating disease Embargoed by the journal Cell Stem Cell until November 4, noon, Eastern time "“ Scripps Research Institute scientists have taken a step closer to understanding the cause of Friedreich's ataxia, a debilitating neurological condition that affects tens of thousands of people worldwide, and so far has no cure. Researchers already know that the disease arises from the silencing of the gene FXN, due to an...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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