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Last updated on April 17, 2014 at 17:30 EDT

Latest DNA repair Stories

2010-09-13 12:40:07

St. Jude Children's Research Hospital scientists discovered a new mechanism cells use to maximize production of a key protein following DNA damage and demonstrated the potential of small molecules to regulate the process and protect healthy tissue St. Jude Children's Research Hospital investigators have identified a novel structure in cells that serves as a control switch in the body's system for eliminating damaged cells and also offers new therapeutic potential. The findings provide fresh...

2010-08-17 17:42:38

A UCSF-led team has discovered at least one key reason why blood stem cells are susceptible to developing the genetic mutations that can lead to adult leukemia. Their finding also may explain, they say, why some other age-related hematological disorders develop. The study, reported in "Cell Stem Cell" (Aug. 6, 2010) and reviewed in Cell Stem Cell and Cell, opens a new frontier for studying the molecular underpinnings of adult leukemia. The discovery also suggests a possible therapeutic...

2010-08-17 17:19:21

Findings show that rather than a straightforward "off-on" switch, the MDM2 oncogene is controlled by a more complicated "dimmer switch" that is sensitive to its changing environment Researchers at Beth Israel Deaconess Medical Center (BIDMC) have uncovered the genes that regulate MDM2, an oncogene that, in turn, regulates the tumor suppressor protein p53. But instead of an on-off switch for MDM2, the team found what looks like a dimmer switch, suggesting a more complicated signaling pathway...

2010-08-12 15:05:00

Molecular connection is crucial to fix DNA double-strand breaks A team of investigators led by a physician-scientist at The University of Texas MD Anderson Cancer Center has shown for the first time that the small protein SUMO can team up with the replication protein A (RPA) complex to facilitate DNA repair. The study is published in the Aug. 13 edition of the journal Molecular Cell. RPA 70 is a component of multiprotein machinery called the RPA complex, which plays a crucial role in DNA...

2010-07-26 12:19:03

Researchers have long known that humans lack a key enzyme -- one possessed by most of the animal kingdom and even plants -- that reverses severe sun damage. For the first time, researchers have witnessed how this enzyme works at the atomic level to repair sun-damaged DNA. The discovery holds promise for future sunburn remedies and skin cancer prevention. In the early online edition of the journal Nature, Ohio State University physicist and chemist Dongping Zhong and his colleagues describe...

2010-07-06 11:00:00

PARIS, July 6 /PRNewswire-FirstCall/ -- Cellectis (Alternext: ALCLS), the French genome engineering specialist, announced today that the Paris Tribunal de Grande Instance has dismissed the claims filed by Taconic Artemis and Taconic Farms Inc in December 2008 against Cellectis' termination for breach of its license to homologous recombination patents. The third chamber of the Tribunal de Grande Instance decided on Tuesday, June 29, that the agreement under which Cellectis had granted...

2010-07-02 19:54:28

Brandeis lab reveals the connection between mutation and malignancy What if we could understand why cancer develops? We know that certain risk factors, such as smoking or excessive sun exposure, can increase the chances of developing this terrible disease, but cancer can form in any tissue, and the cause is not always clear. One idea that has emerged is that for a cell to transform into a cancer cell it must suffer a large number of mutations affecting different genes needed to control cell...

2010-07-02 16:25:29

A new study by researchers at NYU School of Medicine found that UVA radiation damages the DNA in human melanocyte cells, causing mutations that can lead to melanoma. Melanocytes, which contain a substance called melanin that darkens the skin to protect it from the ultraviolet rays of the sun, are more vulnerable to UVA radiation than normal skin cells because they are unable to repair themselves as efficiently. "For the first time, UVA rays have been shown to cause significant damage to the...

2010-07-01 14:19:27

UAB researchers decode a cascade of signals within tumour cells activated by olive oil The researchers decoded a complete cascade of signals within breast tumour cells activated by virgin olive oil, and concluded that benefits include decrease in the activity of the oncogene p21Ras, changes in protein signaling pathways, stimulation of tumour cell death and prevention of DNA damage. The study was carried out in an experimental model and researchers have already begun a new study with human...

2010-06-24 16:07:38

University of Rhode Island Pharmacy Professor Bongsup Cho knows there are cancer-causing chemicals in diesel fumes and cigarette smoke. The biomedical scientist also knows that some of the same chemicals are found in the gooey tar balls that are being produced as a result of the oil spill in the Gulf of Mexico, which began April 20 when a rig exploded and caught fire. But what he and other scientists have little knowledge of is the long-range impact of the spill on humans and wildlife at the...