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Latest DNA repair Stories

2010-01-15 17:38:35

Biomarkers, new treatments possible for Friedreich's ataxia Elevated levels of DNA damage have for the first time been found in the cellular mitochondria and nuclei of patients with the inherited, progressive nervous system disease called Friedreich's ataxia (FRDA), says a multicenter research team led by an expert from the University of Pittsburgh Cancer Institute (UPCI). The findings, described today in PLoS Genetics, shed light on the molecular abnormalities that lead to the disease, as...

2009-12-25 22:02:32

A new study establishes a molecular link that bridges two rare inherited disorders and explains why these diseases result in genetic instability. The research, published by Cell Press in the December 24th issue of the journal Molecular Cell, may lead to a better understanding of the complex mechanisms that enable cells to repair damaged DNA. Fanconi Anemia (FA) and Bloom's Syndrome (BS) are unique rare genetic disorders that have some key characteristics in common. Both FA and BS are...

2009-12-25 21:54:45

In order to preserve our DNA, cells have developed an intricate system for monitoring and repairing DNA damage. Yet precisely how the initial damage signal is converted into a repair response remains unclear. Researchers at the Salk Institute for Biological Studies have now solved a crucial piece of the complex puzzle. In a forthcoming article in the Dec. 24 issue of Molecular Cell, they show that a protein named CtIP plays an essential role in the DNA damage "signal-to-repair" conversion...

2009-12-23 16:54:52

Genome rearrangements in 24 breast cancers The first detailed search of breast cancer genomes to uncover genomic rearrangements is published today. The team characterized the ways in which the human genome is broken and put back together in 24 cases of breast cancer. Rearrangements involve reshuffling and reorganization of the genome and include deletions, duplications and novel juxtaposition of DNA sequences. The study shows that breast cancer samples can differ greatly in the extent to...

2009-12-10 12:56:50

MIT and Boston University researchers have discovered that the drug hydroxyurea kills bacteria by inducing them to produce molecules toxic to themselves "” a conclusion that raises the possibility of finding new antibiotics that use similar mechanisms. Hydroxyurea inhibits the enzyme critical for making the building blocks for DNA, so for decades it has been used to study the consequences of inhibiting DNA replication in E. coli, yeast and mammalian cells. It is also sometimes used in...

2009-12-09 15:10:00

Robarts researcher identifies protein which regulates cell suicide When cells experience DNA damage, they'll try to repair it. But if that fails, the damaged cells are supposed to self-destruct, a process called apoptosis. A cancer researcher at Robarts Research Institute at The University of Western Ontario has identified a protein that regulates apoptosis, a new discovery which has implications for both the diagnosis and treatment of cancer. Caroline Schild-Poulter's findings are now...

2009-12-08 20:03:10

Small molecule plus TMZ appears to lower tumor resistance University of Florida researchers have found a way to use just a fraction of the normal dosage of a highly toxic, debilitating chemotherapy drug to achieve even better results against colon cancer cells. More research is needed before the therapy can be tested in patients, but the discovery in human colon cancer cell lines and mice with established human tumors suggests that the addition of a small molecule to the cancer drug...

2009-12-08 12:02:00

NEW YORK, Dec. 8 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue: Poly(ADP-ribose) polymerase (PARP) Research Products http://www.reportlinker.com/p0167261/PolyADP-ribose-polymerase-PARP-Research-Products.html This PARP Research Products market report explores are a superfamily of 18 proteins, of which PARP-1 is the best characterized. They are enzymes that are activated by DNA breaks to facilitate DNA repair. Currently, there is...

2009-12-04 15:08:06

A protein that plays a key role in copying DNA also plays a vital role in repairing breaks in it, UC Davis scientists have found. The work is helping researchers understand how cancer cells can resist radiation and chemotherapy, as well as how cells become cancerous in the first place. The protein, known as proliferating cell nuclear antigen, forms a ring that fits around the DNA double helix. This cuff-like ring helps to keep in place DNA polymerase, the enzyme that makes a copy of the DNA...

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2009-11-30 09:04:59

Understanding how kangaroos repair their DNA could be the key to preventing skin cancer in the future, according to new research by Dr Linda Feketeová and Dr Uta Wille from the ARC Centre of Excellence for Free Radical Chemistry and Biotechnology at The University of Melbourne. Together with scientists from The University of Innsbruck, Austria, Dr Feketeová and Dr Wille are working toward reducing the number of skin cancer-related cases by investigating the chemistry behind...


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ramage
  • Boughs or branches.
  • Warbling of birds in trees.
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