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Latest DNA repair Stories

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2009-10-16 09:39:00

Research Supports Potential for New Anti-Cancer Agent A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals. In addition, the study provides supportive evidence for the use of inhibitors of ATR in cancer therapy. Essentially, says senior...

2009-10-02 09:14:48

Understanding how serious breaks in DNA are repaired may help researchers to make cancer therapy more effective Researchers at The Scripps Research Institute have found, crystallized, and biologically characterized a poorly defined component of a key molecular complex that helps people to avoid cancer, but that also helps cancer cells resist chemotherapy. The research was published in the October 2, 2009 issue of the journal Cell. This biological machine"”the Mre11-Rad50-Nbs1 (MRN)...

2009-09-29 09:00:00

ROYAL PALM BEACH, Fla., Sept. 29 /PRNewswire/ -- The first anti-aging doctor to offer TA-65 treatment in the U.S., has discovered a way to apply similar technology to skin care. TA-65 is the newest and most dramatic technology in the world of life extension. It is the only commercially available product that lengthens human telomeres - the protective tips that cap the ends of your DNA. Each time your cells divide, your telomeres get shorter. When your telomeres run down, cell division...

2009-09-24 08:02:14

For years, health conscious people have been taking antioxidants to reduce the levels of reactive oxygen in their blood and prevent the DNA damage done by free radicals, which are the result of oxidative stress. But could excessive use of antioxidants deplete our immune systems? Research at UCLA's Jonsson Comprehensive Cancer Center has raised that question. It has been known for decades that reactive oxygen species (ROS) - ions or very small molecules that include free radicals - damage...

2009-09-11 07:50:17

While Fanconi anemia (FA) is a rare and dangerous disease, new laboratory research at The University of Texas M. D. Anderson Cancer Center shows it may lead researchers toward clues in more common diseases, including highly hereditary types of breast cancer. In a study published in the Sept. 11 issue of the journal Molecular Cell, scientists report that recruitment of proteins to DNA damage sites is controlled by replication in both FA and BRCA cancer proteins. Lei Li, Ph.D, professor in...

2009-09-09 10:34:57

Results will be of great relevance to the cosmetics industry Scientists have uncovered a new role played by Vitamin C in protecting the skin. Researchers at the University of Leicester and Institute for Molecular and Cellular Biology in Portugal studied new protective properties of vitamin C in cells from the human skin, which could lead to better skin regeneration. The work, by Tiago Duarte, Marcus S. Cooke and G. Don Jones, found that a form of Vitamin C helped to promote wound healing and...

2009-09-07 14:31:17

A study that tracked genetic mutations through the human equivalent of about 5,000 years has demonstrated for the first time that oxidative DNA damage is a primary cause of the process of mutation - the fuel for evolution but also a leading cause of aging, cancer and other diseases. The research, just published in Proceedings of the National Academy of Sciences, also indicated that natural selection is affecting the parts of the genome that don't contain genes "“ supposedly "junk" DNA...

2009-09-01 07:24:01

Cell cycle checkpoints act like molecular tripwires for damaged cells. Leave the tripwire in place for too long, however, and cancer cells will press on regardless, making them resistant to certain types of chemotherapy, according to researchers at the Salk Institute for Biological Studies. "A lot of progress has been made in understanding the molecular details of checkpoint activation," senior author Tony Hunter, Ph.D., a professor in the Molecular and Cell Biology Laboratory was quoted as...

2009-08-17 13:39:34

Scientists at Dana-Farber Cancer Institute have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing themselves.The findings being reported in the Aug. 14 issue of Molecular Cell help explain the promising results being seen in clinical trials of compounds that force cancer cells with genetic damage to self-destruct instead of "resting" while their DNA undergoes...

2009-08-09 09:31:03

The Stowers Institute's Conaway Lab has uncovered a previously unknown function of a gene product called Amplified in Liver Cancer 1 (Alc1), which may play a role in the onset of cancer. The work was published yesterday by the Proceedings of the National Academy of Science Early Edition."We've been able to demonstrate that the protein encoded by the Alc1 gene is, in fact, a chromatin remodeling enzyme," explained Aaron Gottschalk, lead author on the paper and a University of Kansas Medical...