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Last updated on April 19, 2014 at 5:20 EDT

Latest DNA repair Stories

2009-06-19 13:54:13

Tumor-suppressor recruits help to overcome a barrier and fix cancer-causing defects Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access. Reporting online at Nature Cell Biology this week, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center shows that BRIT1 connects with another protein complex to relax DNA's tight...

2009-06-15 16:36:00

A person's DNA is often damaged by a number of different chemical contaminants, and if not repaired properly, it can lead to the development of cancer and other diseases. Through an international collaboration, University of Alberta researchers Chris Le and Michael Weinfeld have discovered how damaged DNA is recognized and repaired. This could lead to improved treatment of cancer and other diseases.The team, from the Faculty of Medicine & Dentistry, used a new technology to monitor the...

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2009-06-12 15:15:00

Those stubborn grey hairs that come with age really are signs of stress, albeit of the cellular kind, according to a new Japanese study. Genotoxic stress, which is anything that damages our DNA, sets off a chain reaction in which specialized cells known as melanocyte stem cells (MSCs) become damaged, ultimately resulting in a malfunction of the cells responsible for hair color. Scientists discovered that the type of genotoxic stress that damages DNA depletes the MSCs in hair follicles that...

2009-05-05 12:16:02

Vanderbilt-Ingram Cancer Center investigators have uncovered a mechanism that helps explain how lithium, a drug widely used to treat bipolar mood disorder, also protects the brain from damage that occurs during radiation treatments.In the May 1 issue of the Journal of Clinical Investigation, Fen Xia, M.D., Ph.D., and colleagues show that lithium promotes DNA repair in healthy cells but not in brain tumor cells. The findings suggest that lithium treatment could offer a way to protect healthy...

2009-05-04 10:16:28

One can have a dream, two can make that dream so real, goes a popular song. Now a Weizmann Institute study has revealed that it takes two to perform an essential form of DNA repair. Prof. Zvi Livneh of the Weizmann Institute's Biological Chemistry Department has been studying DNA repair for some two decades: "ËœConsidering that the DNA of each cell is damaged about 20,000 times a day by radiation, pollutants and harmful chemicals produced within the body, it's obvious that without...

2009-04-28 13:16:14

U.S. scientists say they've determined immune cells don't kill bacteria by damaging their DNA, reversing a widespread assumption in the scientific community. The University of Illinois researchers said they discovered macrophages -- the immune cells that engulf and kill bacteria -- direct their attack on targets outside the bacteria's membrane-bound cytoplasm. University of Illinois Graduate student Maureen Craig and Professor James Slauch said they discovered macrophages kill bacteria with...

2009-04-28 12:32:32

Some DNA repair enzymes can become double-edged swords "“ If they work too slowly, they can block necessary cell maintenance and contribute to cell death. This could explain the somewhat mysterious success of the widely used cancer drug 5-Fluorouracil (5FU) and help clinicians to predict patient's response to chemotherapy, according to new findings from the University of Basel, Switzerland. The work, published in this week's issue of PLoS Biology, reports that 5FU keeps the DNA-repair...

2009-04-28 11:23:10

 For decades, microbiologists assumed that macrophages, immune cells that can engulf and poison bacteria and other pathogens, killed microbes by damaging their DNA. A new study from the University of Illinois disproves that.The study, published in the journal PLoS ONE, shows that macrophages focus their most potent poisons, known as reactive oxygen species (ROS), on targets outside the cytoplasm.Macrophages are voracious eaters that "swallow" cellular debris and invading organisms. They...

2009-04-21 00:30:00

Identifies potential clinical trial strategies for personalized approach to cancer treatment SEATTLE, April 21 /PRNewswire-FirstCall/ -- Systems Medicine, LLC (SM), a wholly-owned subsidiary of Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC), presented data from a preclinical study, which utilized RNA interference (RNAi) and bioinformatics to identify genetic markers - "contexts of vulnerability" - that enhance the anti-tumor response to the experimental drug candidate brostallicin, at...

2009-04-14 08:08:52

Turns model parasite into genetic workhorse-In a genetic leap that could help fast track vaccine and drug development to prevent or tame serious global diseases, DMS researchers have discovered how to destroy a key DNA pathway in a wily and widespread human parasite. The feat surmounts a major hurdle for targeting genes in Toxoplasma gondii, an infection model whose close relatives are responsible for diseases that include malaria and severe diarrhea."This opens a wide window on a complex...