Latest DNA repair Stories
Researchers at Washington University School of Medicine in St. Louis have shed new light on a process that fixes breaks in the genetic material of the body's cells.
The "sloppier copier" discovered by USC biologists is also the best sixth man in the DNA repair game, an article in the journal Nature shows.
When cells experiencing DNA damage fail to repair themselves, they send a signal to their neighbors letting them know they're in trouble.
A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells.
Catalysts assist in chemical reactions without undergoing any alteration of their own. In the cells of living organisms, proteins perform this important function.
Rearrangements of all sizes in genomes, genes and exons can result from a glitch in DNA copying that occurs when the process stalls at a critical point and then shifts to a different genetic template, duplicating and even triplicating genes or just shuffling or deleting part of the code within them, said researchers from Baylor College of Medicine in a recent report in the journal Nature Genetics.
Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access.
A person's DNA is often damaged by a number of different chemical contaminants, and if not repaired properly, it can lead to the development of cancer and other diseases. Through an international collaboration, University of Alberta researchers Chris Le and Michael Weinfeld have discovered how damaged DNA is recognized and repaired.
Those stubborn grey hairs that come with age really are signs of stress, albeit of the cellular kind, according to a new Japanese study.
Vanderbilt-Ingram Cancer Center investigators have uncovered a mechanism that helps explain how lithium, a drug widely used to treat bipolar mood disorder, also protects the brain from damage that occurs during radiation treatments.
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