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Latest DNA repair Stories

2012-02-14 10:58:31

In this News Digest:     Summary of the first prospective study — published online February 13, 2012 in the Journal of Clinical Oncology — to provide strong evidence of increased breast and pancreatic cancer risk in individuals with Lynch syndrome, who carry certain inherited genetic mutations in DNA repair genes. The study is also the first to show that relatives of people with Lynch syndrome who do not carry these mutations have no increased risk of cancer....

2012-02-09 10:46:32

It's been more than 50 years since James Watson and Francis Crick showed that DNA is a double helix of two strands that complement each other. But how does a short piece of DNA find its match, out of the millions of 'letters' in even a small genome? New work by researchers at the University of California, Davis, handling and observing single molecules of DNA, shows how it's done. The results are published online Feb. 8 by the journal Nature. Defects in DNA repair and copying are strongly...

2012-02-02 22:41:13

Scientists at the University Medical Center in Mainz prove multiple DNA repair defect in monocytes Scientists working with Professor Bernd Kaina of the Institute of Toxicology at the Medical Center of Johannes Gutenberg University Mainz have demonstrated for the first time that certain cells circulating in human blood — so-called monocytes — are extremely sensitive to reactive oxygen species (ROS). They were also able to clarify the reason for this: ROS are aggressive forms of...

2012-01-19 13:50:35

Inherited mutation links exploding chromosomes to cancer An inherited mutation in a gene known as the guardian of the genome is likely the link between exploding chromosomes and some particularly aggressive types of cancer, scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ) and the University Hospital, all in Heidelberg, Germany, have discovered. Their study, published online today in Cell, also presents the first whole genome sequence...

2012-01-11 21:28:13

The chemotherapy drugs required to push a common form of adult leukemia into remission may contribute to DNA damage that can lead to a relapse of the disease in some patients, findings of a new study suggest. The research, by a team of physicians and scientists at Washington University School of Medicine in St. Louis, is published Jan. 11 in the advance online edition of Nature. For patients with acute myeloid leukemia (AML), initial treatment with chemotherapy is essential for putting...

2012-01-03 14:51:00

Scientists have found at least one instance when the smaller sibling gets to call the shots and cancer patients may one day benefit. The protein Chk1 has long been known to be a checkpoint in cell development: it keeps normal cells and damaged cells from dividing until their DNA has been fully replicated or repaired. Now scientists at Georgia Health Sciences University and the California Institute of Technology have discovered a shorter form they've dubbed Chk1-S ("S" stands for short)...

2012-01-03 14:30:16

Aging-related tissue degeneration can be caused by mitochondrial dysfunction in tissue stem cells. The research group of Professor Anu Suomalainen Wartiovaara in Helsinki University, with their collaborators in Max Planck Institute for Biology of Aging, Karolinska Institutet and University of Wisconsin reported on the 3rd January in Cell Metabolism their results on mechanisms of aging-associated degeneration. Stem cells are called the spare parts for tissues, as they maintain and repair...

2011-12-28 07:48:27

Oxidative stress is the cause of many serious diseases such as cancer, Alzheimer's, arteriosclerosis and diabetes. It occurs when the body is exposed to excessive amounts of electrically charged, aggressive oxygen compounds. These are normally produced during breathing and other metabolic processes, but also in the case of ongoing stress, exposure to UV light or X-rays. If the oxidative stress is too high, it overwhelms the body's natural defenses. The aggressive oxygen compounds destroy...

2011-12-23 01:07:20

In eukaryotes — the group of organisms that include humans — a key to survival is the ability of certain proteins to quickly and accurately repair genetic errors that occur when DNA is replicated to make new cells. In a paper published in the December 23, 2011 issue of the journal Science, researchers at the Ludwig Institute for Cancer Research and the University of California, San Diego School of Medicine have solved part of the mystery of how these proteins do their job, a...

2011-12-20 18:30:44

Berkeley Lab Researchers Find Evidence Suggesting Risk May Not Be Proportional to Dose at Low Dose Levels Researchers with the U.S. Department of Energy (DOE)´s Lawrence Berkeley National Laboratory (Berkeley Lab), through a combination of time-lapse live imaging and mathematical modeling of a special line of human breast cells, have found evidence to suggest that for low dose levels of ionizing radiation, cancer risks may not be directly proportional to dose. This contradicts the...


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