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Latest DNA repair Stories

2011-10-24 10:15:15

Findings suggest how cancer cells can become resistant to DNA damage-inducing treatments An international team of scientists led by UC Davis researchers has discovered that DNA repair in cancer cells is not a one-way street as previously believed. Their findings show instead that recombination, an important DNA repair process, has a self-correcting mechanism that allows DNA to make a virtual u-turn and start over. The study's findings, which appear in the Oct. 23 online issue of the...

2011-10-19 12:58:51

Researchers from Massachusetts General Hospital, Harvard Medical School and CIC bioGUNE discover a complex cell mechanism activated by a protein –HOXB9– that becomes an obstacle for radiation effectiveness. Scientists all over the world continue to focus their research on breast cancer. As a consequence, knowledge of the behavior of tumor cells is growing, as well as of their interactions with the microenvironment. There are, however, many questions still unanswered. A new...

2011-10-12 23:11:52

New gene therapy methods accurately correct mutation in patient's stem cells, bringing personalized cell therapies one step closer For the first time, scientists have cleanly corrected a human gene mutation in a patient's stem cells. The result, reported in Nature on Wednesday 12 October, brings the possibility of patient-specific therapies closer to becoming a reality. The team, led by researchers from the Wellcome Trust Sanger Institute and the University of Cambridge, targeted a gene...

2011-10-12 10:40:04

DNA-damaging platinum drugs work better against them; BRCA1 variations have no effect Women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations, researchers at The University of Texas MD Anderson Cancer Center and the Institute for Systems Biology report in the Oct. 12 issue of the Journal of the American Medical Association. "BRCA2-mutated tumors are more vulnerable to these DNA-damaging agents,...

2011-09-27 15:15:12

Clemson University researchers recently reported finding a new class of DNA repair-makers. Clemson biochemist Weiguo Cao studies how cells repair damaged DNA. The finding from Cao's lab in the Clemson Biosystems Research Complex in collaboration with computational chemist Brian Dominy appeared in the Sept. 9 issue of The Journal of Biological Chemistry: "A new family of deamination repair enzymes in the uracil DNA glycosylase superfamily by Hyun-Wook Lee, Brian N. Dominy and Weiguo Cao."...

2011-09-07 14:01:50

Feedback mechanism coordinates cellular respiration and the degradation of free oxygen radicals Oxygen-consuming organisms obtain energy through cellular respiration, which is the transformation of carbohydrates and oxygen into carbon dioxide and water. This process also produces toxic oxygen radicals which must be decomposed immediately, as they would otherwise cause damage to cells. Scientists from the Max Planck Institute for Molecular Genetics in Berlin have now discovered a mechanism,...

2011-09-01 15:32:02

It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers at Virginia Commonwealth University Massey Cancer Center have shown that certain BRCA1 mutations result in excessive, uncontrolled DNA repair, which challenges the prior assumption that mutations in BRCA1 only contribute to breast cancer through a reduction in...

2011-07-29 13:03:11

Telomeres, the complex structures that protect the end of chromosomes, of peripheral blood cells are significantly shorter in patients with familial breast cancer than in the general population. Results of the study carried out by the Human Genetics Group of the Spanish National Cancer Research Centre (CNIO), led by Javier Benitez, to be published in open-access journal PLoS Genetics on July 28th, reflect that familial, but not sporadic, breast cancer cases are characterized by shorter...

2011-07-19 15:07:57

Hallmark of cancer cells Scientists from the Hebrew University have identified the molecular basis for DNA breakage, a hallmark of cancer cells. The findings of this research have just been published in the journal Molecular Cell. The DNA encodes the entire genetic information required for building the proteins of the cell. Hence, DNA breaks disrupt the proteins and lead to changes in the cell function. These changes can lead to defects in the control of cellular proliferation resulting in...


Word of the Day
grass-comber
  • A landsman who is making his first voyage at sea; a novice who enters naval service from rural life.
According to the OED, a grass-comber is also 'a sailor's term for one who has been a farm-labourer.'