Latest DNA replication Stories
A study led by Oscar Fernandez-Capetillo has deciphered the components of the machinery that duplicates DNA, the replisome, on which most chemotherapeutic agents currently act The Genomic Instability Group led by researcher Óscar Fernández-Capetillo at the Spanish National Cancer Research Centre (CNIO), has for the first time obtained a panoramic photo of the proteins that take part in human DNA division, a process known as replication. The research article, published today in the...
Scientists have revealed how a bacterial enzyme has evolved an energy-efficient method to move long distances along DNA. The findings, published in Science, present further insight into the coupling of chemical and mechanical energy by a class of enzymes called helicases, a widely-distributed group of proteins, which in human cells are implicated in some cancers. The new helicase mechanism discovered in this study, led by researchers from the University of Bristol and the Technische...
Like finally seeing all the gears of a watch and how they work together, researchers from UCLA and UC Berkeley have, for the first time ever, solved the puzzle of how the various components of an entire telomerase enzyme complex fit together and function in a three-dimensional structure. The creation of the first complete visual map of the telomerase enzyme, which is known to play a significant role in aging and most cancers, represents a breakthrough that could open up a host of new...
redOrbit Staff & Wire Reports - Your Universe Online Scientists at Penn State University have discovered how a vital step in the human DNA replication process – the loading of molecular structures known as sliding clamps onto DNA molecules – is performed. The researchers say their work, the results of which were published in Tuesday’s edition of the journal eLife, will help uncover some of the mystery surrounding this crucial part of the chemical replication process. This step...
SAN DIEGO, March 7, 2013 /PRNewswire/ -- TriLink BioTechnologies, Inc. (TriLink, trilinkbiotech.com) has granted Dr. Aaron Leconte of the WM Keck Science Department of Claremont McKenna, Pitzer and Scripps Colleges a ResearchReward for mutant polymerase research. "The use of DNA biotechnologies is often limited by which DNA polymerases recognize which modified nucleotide analogs," stated Dr. Leconte. "In my lab, we are working on discovering DNA polymerases with novel substrate...
Protein uses multiple means to help cells cope when oxygen runs low A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying — known as DNA replication — and new cell growth to many of the body's functions and in such diseases as cancer....
The TA-65 Users Survey included the collection of qualitative data gathered through survey research. This study outlined the TA-65 longevity and health benefits seen in actual human subjects, during the course of the 6 months. New York, NY (PRWEB) February 17, 2013 Telomeres are protective pieces of DNA material at the ends of every chromosome in every cell in the body. Telomeres, like protective caps at the end of our shoelaces, function to protect the integrity of the genome and...
One approach to understanding components in living organisms is to attempt to create them artificially, using principles of chemistry, engineering and genetics. A suite of powerful techniques—collectively referred to as synthetic biology—have been used to produce self-replicating molecules, artificial pathways in living systems and organisms bearing synthetic genomes. In a new twist, John Chaput, a researcher at Arizona State University’s Biodesign Institute and colleagues at the...
Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now identified a previously unknown mechanism in the regulation of OIS. This study is published online in advance of the January issue of The American Journal of Pathology. In many types...
MENLO PARK, Calif., Nov. 28, 2012 /PRNewswire/ -- Telome Health, Inc. (THI), developer of the TeloTest(TM) diagnostic test that measures average telomere length, announces the planned launch of the saliva-based TeloTest in the first quarter of 2013. Related telomere tests, including percentage of short telomeres, would follow. Telome Health's TeloTest(TM) will be the first saliva-based telomere test available on the market. THI leverages the predictive power of data related to...
